Improving diagnosis of legume allergies
Official title: Comparison of Prick-to-prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis (CRD) in Diagnosing of Allergy to Peas, Lentils, Chickpeas and Green Beans
Run by University Hospital Pilsen · NCT06923878 · Data updated 2026-11-12
This study is testing a new way to diagnose legume allergies, like those to peas and lentils, to see if it works better than the usual allergy tests.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Months to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital Pilsen Academic / other |
| Locations | 1 site (Pilsen, Czech Republic) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | October 1, 2028 |
| Study ends | March 31, 2029 |
| Registry record updated | April 9, 2026 |
| Trial ID | NCT06923878 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 65 or younger with a history of immediate allergic reactions to legumes and positive allergy test results.
✕Probably not a fit
Patients with a history of severe systemic allergic reactions to legumes or those unwilling to undergo an oral food challenge may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance the diagnosis of food allergies, particularly to legumes like peas, lentils, chickpeas, and green beans. It will compare traditional allergy testing methods, including skin prick tests and specific IgE antibody testing, with a newer approach that tests for specific IgE antibodies against allergenic molecules in legumes. The effectiveness of these tests will be evaluated against the oral food challenge, which is the gold standard for diagnosing food allergies. The study seeks to address the often-overlooked prevalence of legume allergies and improve diagnostic accuracy.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of legume allergies, improving patient management and safety.
How similar studies have gone: While there is limited research specifically on the diagnosis of legume allergies using these methods, similar approaches in food allergy diagnostics have shown promise.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age: ≤ 65 years * signing informed consent to the study * a positive history of an immediate allergic reaction to one or more of the legumes studied (peas, lentils, chickpeas, beans) with skin, gastrointestinal, respiratory or cardiovascular symptoms occurring within 2 hours after ingestion and a positive result of specific IgE testing against ALEX and/or skin prick test with the legume * patients with a positive OFC with any of the legumes studied Exclusion Criteria: * disagreement with the implementation of the oral food challenge * history of severe systemic allergic reaction to the legume in question (Ring-Messmer grade ≥ 3)
Where it's running
-
University Hospital Pilsen
Pilsen, Czech Republic, Czechia Recruiting
Study contacts
- Principal investigator: Martin Liska, MD — Department of allergology and immunology
- Study coordinator: Martin Liska, MD
- Email: liska@fnplzen.cz
- Phone: +420377103390
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.