Improving detection of cancerous lymph nodes during breast cancer surgery
Intraoperative Imaging of Indocyanine Green for Sentinel Lymph Node Mapping
This study is testing new imaging technologies to see if they can help doctors find cancerous lymph nodes more accurately during breast cancer surgery, which could lead to better outcomes for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 48 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Skopje) |
| Trial ID | NCT06276439 on ClinicalTrials.gov |
What this trial studies
This study evaluates new imaging technologies designed to enhance the detection of cancerous sentinel lymph nodes in breast cancer patients during surgery. By utilizing a bioinspired imaging sensor and a low noise imaging sensor, the research aims to improve the accuracy of identifying positive lymph nodes using the FDA-approved fluorescent probe Indocyanine Green (ICG). The study will analyze fluorescence from ex vivo resected samples to determine the effectiveness of these imaging methods compared to traditional visual inspection. The ultimate goal is to minimize the need for additional surgeries and improve patient outcomes by ensuring only cancerous lymph nodes are removed.
Who should consider this trial
Good fit: Ideal candidates are individuals with early or progressive stage breast cancer who require surgical intervention.
Not a fit: Patients who are pregnant, have a history of breast cancer surgery, or have allergies to iodide or seafood will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate surgeries, reducing the need for follow-up procedures and improving the quality of life for breast cancer patients.
How similar studies have performed: While the use of imaging technologies in cancer surgery is established, this specific bioinspired approach is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * early or progressive stage of breast cancer who needs to be treated with breast surgery Exclusion Criteria: * pregnant women * previous breast cancer surgery * history of allergic reactions to iodide or seafood allergy. * man
Where this trial is running
Skopje
- University Clinic Hospital — Skopje, North Macedonia (Recruiting)
Study contacts
- Principal investigator: Viktor Gruev, PhD — University of Illinois Urbana Champaign
- Study coordinator: Viktor Gruev, PhD
- Email: vgruev@illinois.edu
- Phone: +1.267.847.4020
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.