Improving brain blood flow in chronic kidney disease through exercise
Cerebrovascular Dysregulation in Chronic Kidney Disease
This study is testing if regular exercise can help improve blood flow to the brain in people with chronic kidney disease to reduce their risk of stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 75 Years |
| Sex | All |
| Sponsor | University of North Texas, Denton, TX Academic / other |
| Locations | 1 site (Denton, Texas) |
| Trial ID | NCT05571605 on ClinicalTrials.gov |
What this trial studies
This study aims to determine if regular exercise training can enhance brain blood flow regulation in patients with chronic kidney disease (CKD). It builds on previous findings that CKD patients are at a higher risk of stroke due to impaired brain blood flow regulation. Participants will engage in either exercise on a stationary bicycle or stretching exercises three times a week for 12 weeks to assess improvements in dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with chronic kidney disease stages III-IV who can participate in exercise.
Not a fit: Patients with heart failure, chronic obstructive pulmonary disease, or those unable to exercise on a stationary bicycle may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved brain health and reduced stroke risk for patients with chronic kidney disease.
How similar studies have performed: While there is existing research on exercise benefits in chronic diseases, this specific approach to improving brain blood flow regulation in CKD is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Individuals with chronic kidney disease stages III-IV. Exclusion Criteria: * Heart failure * Chronic obstructive pulmonary disease * Uncontrolled hypertension or hypotension * Pregnancy or plans to become pregnant * Inability to exercise on a stationary bicycle * Current participation in exercise more than 20 minutes twice per week
Where this trial is running
Denton, Texas
- University of North Texas — Denton, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Justin Sprick, PhD
- Email: justin.sprick@unt.edu
- Phone: 940-565-2226
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.