Improving bowel preparation for colonoscopy in people with IBD

Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients: A National Multicenter Prospective Study

This project will test whether current bowel-prep practices and individual patient factors affect how clean the bowel is for people with IBD having a colonoscopy.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Changhai Hospital (other)
• Locations: 1 site (Shanghai, Shanghai Municipality)
• Trial ID: NCT07335705 on ClinicalTrials.gov

What this trial studies

Patients scheduled for colonoscopy at participating hospitals will be approached before the procedure or within seven days after their colonoscopy to give informed consent and complete a detailed questionnaire. The questionnaire records patient factors (eg, BMI, surgery history, diabetes, bowel habits) and specifics of the bowel-preparation protocol (diet, cleansing agent, dose, timing, and interval before colonoscopy). Clinicians will record Boston Bowel Preparation Scale scores for each segment and collect colonoscopy diagnoses and endoscopic activity scores. Data will be used to describe current protocol implementation since the 2023 guidelines, identify risk factors for poor preparation, and develop a prediction model to guide personalized regimens.

Who should consider this trial

Good fit: Adults (18 years and older) with a diagnosis of IBD per the 2023 guidelines who are scheduled for colonoscopy and can provide informed consent are ideal candidates.

Not a fit: Patients with recent major myocardial infarction, severe cardiac/hepatic/renal failure, active anticoagulant use or coagulation disorders, pregnancy or lactation, recent acute intestinal infection, colorectal tumors or obstruction, or severe cognitive or hearing impairment are excluded and unlikely to benefit.

Why it matters

Potential benefit: If successful, this work could enable personalized bowel-prep plans that produce cleaner colons, reduce repeat procedures, and improve diagnostic accuracy for people with IBD.

How similar studies have performed: Prior work in general colonoscopy populations has identified risk factors and produced prediction tools for poor bowel prep, but IBD-specific, post-2023-guideline data and validated models remain limited.

Eligibility criteria

Inclusion Criteria:

* Patients aged 18 years or older, of any gender, scheduled for colonoscopy;
* Patients diagnosed with Inflammatory Bowel Disease (IBD) according to the 2023 edition of the Guidelines for the Diagnosis and Treatment of Inflammatory Bowel Disease;
* Voluntary participation in this study and provision of signed informed consent.

Exclusion Criteria:

* History of acute myocardial infarction (within the past 6 months), severe cardiac, hepatic, or renal insufficiency, or psychiatric disorders;
* Current use of anticoagulants (e.g., aspirin, warfarin) or presence of coagulation disorders;
* Pregnant or lactating women;
* Acute intestinal infection within the past 2 weeks;
* History of colorectal tumors, familial adenomatous polyposis, or Peutz-Jeghers syndrome;
* History of intestinal obstruction, perforation, stenosis, or any other condition preventing completion of the examination;
* Severe hearing impairment, cognitive dysfunction, or inability to cooperate with the survey;
* Individuals already enrolled in this study who schedule a repeat colonoscopy;
* Currently participating in another clinical observational trial or having participated in any other clinical trial within the past 60 days;
* Refusal to sign the written informed consent form.

Where this trial is running

Shanghai, Shanghai Municipality

• Changhai Hospital — Shanghai, Shanghai Municipality, China (RECRUITING)

Study contacts

• Study coordinator: Zhao-shen Li, M.D.

Conditions: IBD, Colonoscopy, Colonoscopy: Bowel Preparation, Bowel preparation