Improving blood lipid management for patients with symptomatic intracranial artery stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of combining conventional lipid management with PCSK9 inhibitors in patients suffering from moderate to severe symptomatic intracranial atherosclerotic stenosis. Participants will receive either standard statin therapy or the combination treatment to assess the impact on reducing recurrent stroke incidence. The study focuses on patients with elevated LDL cholesterol levels who have not undergone endovascular therapy. The goal is to determine if enhanced lipid management can lead to better clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years
2. Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
3. low density lipoprotein cholesterol \> 70mg/dl (1.8mmol/L)
4. Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
5. Lipid-lowering indications of statins
6. Signed an approved informed consents

Exclusion Criteria:

1. Contraindications to statins
2. There are contraindications to MRI examination or cannot accept MRI examination
3. Stenosis caused by vasculitis, arterial dissection and moyamoya disease
4. Patients with active bleeding or obvious bleeding tendency
5. Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating
6. Uncontrolled severe diabetes and hypertension
7. Other conditions inappropriate for inclusion judged by investigators

Where it's running

• Nanjing First Hospital, Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting
• Nanjing First Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Junshan Zhou
• Email: zhjsh333@126.com
• Phone: 8602587726218

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gut microbiome links to outcomes in intracranial arterial stenosis

  This project will see if gut microbiome, metabolite, and gene-expression patterns relate to recovery, artery plaque features, and non-motor problems (thinking, mood, and fatigue) in people aged 30-80 with intracranial arterial stenosis.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT07085299

• PCSK9 inhibitor plus statin for reversing asymptomatic intracranial artery plaque

  This trial will test whether adding a PCSK9 inhibitor to statin therapy can shrink plaque and improve narrowing in adults aged 18–60 with asymptomatic intracranial artery stenosis (≥50%).

  Recruiting at 2 sites Phase 4 Peking Union Medical College Hospital · Beijing, Beijing Municipality and 18 other locations · NCT06902740

• Evaluating a new drug-eluting stent for treating intracranial artery stenosis in China

  This study is testing a new type of stent to see if it can safely help people in China with narrowing arteries in the brain and reduce their risk of stroke or death.

  Recruiting at 5 sites Sino Medical Sciences Technology Inc. · Chenzhou and 4 other locations · NCT05692882

• Tirofiban treatment for patients with high-risk cerebrovascular events

  This study is testing whether the drug tirofiban can help prevent new strokes in people aged 40 and older who have had serious but non-disabling cerebrovascular events.

  Recruiting at 5 sites Phase 3 Beijing Tiantan Hospital · Harbin, Heilongjiang and 4 other locations · NCT06319846

• Imaging of atherosclerotic plaques in arteries using advanced MRI techniques

  This study is testing a new MRI technique to see if it can give better pictures of artery plaques in people with moderate to severe narrowing of the arteries, helping to understand their risk for stroke.

  Recruiting Shanghai Jiao Tong University Affiliated Sixth People's Hospital · Shanghai · NCT06754956

• Comparing blood-thinning therapies for patients with severe intracranial artery narrowing

  This study is testing how well different blood-thinning medications work for stroke patients with severe narrowing of the arteries in the brain, using MRI scans to find out who might not be responding to treatment.

  Recruiting at 14 sites Yale University · Birmingham, Alabama and 27 other locations · NCT05907629

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.