Improving blood flow and muscle function in stroke survivors
Blood Flow Regulation and Neuromuscular Function Post-Stroke
This study is testing if a special treatment can improve blood flow and help leg muscles work better for people who have had a stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 2 sites (Milwaukee, Wisconsin and 1 other locations) |
| Trial ID | NCT06027294 on ClinicalTrials.gov |
What this trial studies
This study investigates how blood flow is regulated in the leg muscles of stroke survivors, focusing on the relationship between blood flow and muscle fatigue. It aims to understand the effects of ischemic conditioning, a non-invasive intervention, on muscle fatigue resistance and functional sympatholysis in stroke patients. The study will recruit 60 chronic stroke survivors and 20 age- and sex-matched controls, conducting multiple laboratory visits to assess muscle performance and fatigue. The findings could provide insights into enhancing rehabilitation strategies for stroke survivors.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-85 who are at least six months post-diagnosis of a unilateral cortical or sub-cortical stroke.
Not a fit: Patients with conditions contraindicating ischemic conditioning, such as peripheral vascular disease or chronic pain syndromes, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation techniques that enhance muscle function and endurance in stroke survivors.
How similar studies have performed: While the specific approach of ischemic conditioning in stroke survivors may be novel, similar interventions have shown promise in improving muscle function in other populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be between 18-85 years of age * Able to give informed consent * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke * English speaking Exclusion Criteria: * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) * Chronic pain syndrome * Low back or hip pain that interferes with lower extremity motor testing * History of head trauma * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Inability to follow 2 step commands * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg * Pregnancy or breastfeeding.
Where this trial is running
Milwaukee, Wisconsin and 1 other locations
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)
- Marquette University — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Study coordinator: Matthew Durand, Ph.D.
- Email: mdurand@mcw.edu
- Phone: 4149555619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.