Improving blood flow and muscle function in stroke survivors
Official title: Blood Flow Regulation and Neuromuscular Function Post-Stroke
Run by Medical College of Wisconsin · NCT06027294 · Data updated 2026-11-12
This study is testing if a special treatment can improve blood flow and help leg muscles work better for people who have had a stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 2 sites (Milwaukee, Wisconsin and 1 other locations) |
| Status | Recruiting |
| Started | January 11, 2024 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT06027294 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 18-85 who are at least six months post-diagnosis of a unilateral cortical or sub-cortical stroke.
✕Probably not a fit
Patients with conditions contraindicating ischemic conditioning, such as peripheral vascular disease or chronic pain syndromes, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how blood flow is regulated in the leg muscles of stroke survivors, focusing on the relationship between blood flow and muscle fatigue. It aims to understand the effects of ischemic conditioning, a non-invasive intervention, on muscle fatigue resistance and functional sympatholysis in stroke patients. The study will recruit 60 chronic stroke survivors and 20 age- and sex-matched controls, conducting multiple laboratory visits to assess muscle performance and fatigue. The findings could provide insights into enhancing rehabilitation strategies for stroke survivors.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation techniques that enhance muscle function and endurance in stroke survivors.
How similar studies have gone: While the specific approach of ischemic conditioning in stroke survivors may be novel, similar interventions have shown promise in improving muscle function in other populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be between 18-85 years of age * Able to give informed consent * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke * English speaking Exclusion Criteria: * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) * Chronic pain syndrome * Low back or hip pain that interferes with lower extremity motor testing * History of head trauma * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Inability to follow 2 step commands * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg * Pregnancy or breastfeeding.
Where it's running
-
Medical College of Wisconsin
Milwaukee, Wisconsin, United States Recruiting -
Marquette University
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Study coordinator: Matthew Durand, Ph.D.
- Email: mdurand@mcw.edu
- Phone: 4149555619
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
-
Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
-
Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.