Improving balance and control for below-knee amputees using advanced prosthetics
Official title: Toward Restoration of Normative Postural Control and Stability Using Neural Control of Powered Prosthetic Ankles
Run by North Carolina State University · NCT06452186 · Data updated 2026-11-12
This study tests if using advanced powered prosthetic ankles controlled by muscle signals can help people with below-knee amputations improve their balance and movement compared to regular prosthetics.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | North Carolina State University Academic / other |
| Locations | 1 site (Raleigh, North Carolina) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | May 30, 2028 |
| Study ends | July 30, 2028 |
| Registry record updated | July 14, 2026 |
| Trial ID | NCT06452186 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are unilateral below-knee amputees aged 18 or older, with at least one year of experience using their prosthetic leg and a K-level of 2 or higher.
✕Probably not a fit
Patients with very short residual limbs, cognitive or visual impairments, or those who cannot ambulate independently may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of direct electromyographic (dEMG) control on powered prosthetic ankles for individuals with below-knee amputations. Participants will undergo physical therapy-guided training to enhance their balance, postural stability, and neuromuscular coordination while using a powered prosthetic. The study compares outcomes between those using dEMG-controlled prosthetics and those using standard passive prosthetics. Evaluations will focus on functional tasks and cognitive load during locomotion across multiple lab visits.
Why it matters
Potential benefit: If successful, this approach could significantly enhance the mobility and quality of life for below-knee amputees.
How similar studies have gone: While the use of powered prosthetics is an emerging field, studies exploring dEMG control have shown promising results, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older; * unilateral bower limb amputee * K-level 2 or higher (who are frequent prosthesis users and may benefit from the proposed prosthesis training and use of dEMG controlled powered prosthesis) * Amputation occurred over 2 years ago * At least 1 year of experience using their prosthetic leg * Has used the current socket for at least 6 months without a significant skin issue or major modification * Are willing to come to NC State University's Centennial Campus to participate in research and be photographed while doing research activities Exclusion Criteria: * Have a very short residual shank (the length of the residual limb is ≤15% of the length of intact limb) * Cannot perform functional ambulation in the community on a daily basis without assistive devices * Cognitive or visual impairment that affects the participant's ability to provide informed consent or to follow simple instructions during the experiments * Congenital amputees * Amputees who use powered prosthetic ankles * Weight more than 300lbs * Pregnant Person * Allergic to latex, which is often contained in medical tapes.
Where it's running
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North Carolina State University
Raleigh, North Carolina, United States Recruiting
Study contacts
- Principal investigator: He Huang, PhD — NC State University
- Study coordinator: Neuromuscular Rehabilitation Engineering Laboratory
- Email: nrel.ncsu.contact@gmail.com
- Phone: 919-513-3840
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.