Improving Atrial Fibrillation Treatment with New Ablation Techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness and safety of combining quantitative superior vena cava isolation (SVCI) with pulmonary vein isolation (PVI) for patients suffering from paroxysmal atrial fibrillation (PAF). Participants will be randomly assigned to receive either standard PVI or PVI plus quantitative SVCI, with a follow-up period of 12 months to assess outcomes. The study aims to establish a standardized ablation procedure that minimizes risks while maximizing efficacy through the use of a quantitative ablation index. By addressing the limitations of previous SVCI studies, this trial seeks to provide clearer insights into the potential benefits of this combined approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Symptomatic paroxysmal AF that are unresponsive to antiarrhythmic drugs (one or more than one).
* Willing to undergo catheter ablation for AF.
* Age: 40-75 years old.

Exclusion Criteria:

* History of any type of catheter ablation for cardiac arrhythmias.
* History of any type of thoracic surgery, including cardiac surgery.
* History of malignant tumors.
* History of permanent pacemaker implantation.
* Peripherally inserted central catheter for long-term
* Heart failure (left ventricular ejection fraction ≤40% or NYHA class III\~IV).
* Sinus node dysfunction
* Allergy to contrast agents.
* Pregnancy or lactation.
* Age: \<40yrs or \>75yrs.

Where it's running

• Chinese Academy of Medical Science, Fuwai hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Jun Liu, MD, PhD — Chinese Academy of Medical Sciences, Fuwai Hospital
• Study coordinator: Wenchi Guan, MD, PhD
• Email: wenchi.guan@outlook.com
• Phone: +8613521270747

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.