Improving antibiotic stewardship in general practice

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a two-arm, cluster-randomised hybrid implementation trial comparing an Integrated Network (face-to-face) delivery of antimicrobial stewardship activities with a Virtual Network (online) delivery across 40 general practices in New South Wales, Queensland, Tasmania, and Victoria. Participating doctors will record how often they use stewardship resources and which interventions they prefer, while practices provide consultation counts and patients who saw participating doctors will be invited to give feedback via SMS surveys. Data are collected during a five-month baseline winter period, followed by implementation activities and a five-month post-implementation winter period, with the primary outcome measured as AMS interventions used per 100 consultations. Secondary outcomes use the RE-AIM framework to capture reach, effectiveness, adoption, implementation fidelity, and maintenance.

Why it matters

Who can join: the full rules

Study sites

Inclusion Criteria:

1. New South Wales, Queensland, Tasmania, or Victoria
2. at least two GPs per practice consent to be in the study,
3. that at least one member of practice staff consents to be in the study
4. that a staff member from the site will be available to provide 90 minutes per fortnight of administrative support for the study. There are no exclusion criteria in addition to this.

Exclusion Criteria: None

Participating doctors and healthcare workers

Inclusion criteria:

1\) Working at a participating practice for at least three days a week. Exclusion criteria : None

Patients completing patient reported outcome measure survey

Inclusion criteria:

1. patients consulted with a participating GP for a RTI,
2. patients re-consulted with a GP or was hospitalized. Exclusion criteria: None

Patient reported experience measures survey

Inclusion criteria:

1\) patient consulted with a participating GP for an RTI. Exclusion criteria: None

Patients participating in interviews as part of the nested case studies

Inclusion criteria:

1. consulted with a participating GP for a RTI,
2. completed a patient survey,
3. able to read and speak English Exclusion criteria: None

Where it's running

• University of Wollogongong
  Wollongong, New South Wales, Australia Recruiting
• Bond University
  Gold Coast, Queensland, Australia Recruiting
• University of Tasmania
  Hobart, Tasmania, Australia Recruiting
• Monash University
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Andrew Bonney, PhD, — Graduate School of Medicine, University of Wollongong
• Study coordinator: Colin H Cortie, PhD
• Email: optimas-gp@uow.edu.au
• Phone: +67 02 4221 5610

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Impact of a climate-resilient WASH package in Karamoja schools

  This study tests a climate-resilient water, sanitation and hygiene package in severely water-insecure primary schools in Karamoja to see if it reduces diarrhea and respiratory infections and improves attendance, especially among girls.

  Recruiting Unicef · Moroto · NCT07823231

• Clinical Multimodal Surveillance of Respiratory Pathogens

  This nationwide study tests a hospital-based system to track respiratory pathogens in patients with respiratory symptoms and to use samples collected during care to spot trends and support prevention efforts.

  Recruiting at 31 sites Huashan Hospital · Beijing, Beijing Municipality and 30 other locations · NCT07694648

• Virological Monitoring of Seasonal Respiratory Infections in France

  This project tests how often common respiratory viruses show up in patients seen by primary care doctors in metropolitan France during the fall and winter.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT07599449

• Prevention with PMBL for recurrent RTIs in kids

  This study tests whether PMBL sublingual tablets can help prevent recurrent respiratory tract infections in children aged 3–12 compared to a placebo.

  Recruiting at 9 sites Phase 4 Lallemand Pharma AG · Bialystok and 9 other locations · NCT07578012

• Hormone replacement therapy and respiratory infection risk in postmenopausal women

  This project tests whether hormone replacement therapy changes the chance and severity of respiratory infections in postmenopausal women who wear a smartwatch for six months.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07292857

• Respiratory infections in newborns and children up to five years

  This project will follow newborns in Colombia and Panamá through age five to see how often respiratory infections happen, which germs cause them, and how those infections affect long-term lung health.

  Recruiting at 2 sites Centro de Estudios en Infectogía Pediatrica · Cali, Valle del Cauca Department and 1 other locations · NCT07249996

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.