Improving airway clearance in ICU patients on mechanical ventilation
Preoxygenation for Tracheal Aspirations in Intensive Care, a Randomized Controlled Trial
This study tests if giving extra oxygen before suctioning helps ICU patients on ventilators breathe better and avoid heart problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 2260 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06421012 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of preoxygenation on endotracheal suctioning in ICU patients who are on invasive mechanical ventilation. It compares patients who receive additional preoxygenation before suctioning to those who do not, aiming to assess the impact on oxygen saturation and potential cardiac complications. The study is designed to address the risks associated with suctioning procedures and to evaluate whether preoxygenation can effectively prevent desaturation events. The findings could lead to improved protocols for airway management in critically ill patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are hospitalized in the ICU and have been on invasive mechanical ventilation for less than 24 hours.
Not a fit: Patients on ECMO, pregnant individuals, or those under legal protection may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance patient safety and reduce complications during airway suctioning in ICU settings.
How similar studies have performed: While there have been studies on airway management, the specific approach of preoxygenation prior to suctioning in this context is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * Hospitalized in ICU, under invasive mechanical ventilation for less than 24 hours * Information and signature of consent by patient or relative/trusted person, or emergency inclusion procedure Exclusion Criteria: * Patient on ECMO * Not affiliated to a social security system * Pregnant * Under legal protection (curatorship, guardianship or safeguard of justice) * Patient under AME * Patient included in another interventional study that may have an impact on the evaluation criteria of the present study
Where this trial is running
Paris
- Hôpital Pitié Salpêtrière — Paris, France (Recruiting)
Study contacts
- Principal investigator: Claire FAZILLEAU — Hôpital Pitié Salpêtrière - Assistance Publique Hôpitaux de Paris
- Study coordinator: Claire FAZILLEAU
- Email: claire.fazilleau@aphp.fr
- Phone: 01 42 16 22 75
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.