Improving airway clearance in ICU patients on mechanical ventilation
Official title: Preoxygenation for Tracheal Aspirations in Intensive Care, a Randomized Controlled Trial
Run by Assistance Publique - Hôpitaux de Paris · NCT06421012 · Data updated 2026-11-12
This study tests if giving extra oxygen before suctioning helps ICU patients on ventilators breathe better and avoid heart problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2260 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | January 7, 2025 |
| Main results expected | October 10, 2027 |
| Study ends | December 10, 2027 |
| Registry record updated | May 11, 2025 |
| Trial ID | NCT06421012 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are hospitalized in the ICU and have been on invasive mechanical ventilation for less than 24 hours.
✕Probably not a fit
Patients on ECMO, pregnant individuals, or those under legal protection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of preoxygenation on endotracheal suctioning in ICU patients who are on invasive mechanical ventilation. It compares patients who receive additional preoxygenation before suctioning to those who do not, aiming to assess the impact on oxygen saturation and potential cardiac complications. The study is designed to address the risks associated with suctioning procedures and to evaluate whether preoxygenation can effectively prevent desaturation events. The findings could lead to improved protocols for airway management in critically ill patients.
Why it matters
Potential benefit: If successful, this approach could enhance patient safety and reduce complications during airway suctioning in ICU settings.
How similar studies have gone: While there have been studies on airway management, the specific approach of preoxygenation prior to suctioning in this context is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * Hospitalized in ICU, under invasive mechanical ventilation for less than 24 hours * Information and signature of consent by patient or relative/trusted person, or emergency inclusion procedure Exclusion Criteria: * Patient on ECMO * Not affiliated to a social security system * Pregnant * Under legal protection (curatorship, guardianship or safeguard of justice) * Patient under AME * Patient included in another interventional study that may have an impact on the evaluation criteria of the present study
Where it's running
-
Hôpital Pitié Salpêtrière
Paris, France Recruiting
Study contacts
- Principal investigator: Claire FAZILLEAU — Hôpital Pitié Salpêtrière - Assistance Publique Hôpitaux de Paris
- Study coordinator: Claire FAZILLEAU
- Email: claire.fazilleau@aphp.fr
- Phone: 01 42 16 22 75
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.