Improve profile of the jawline using Restylane Shaype
Official title: A Randomized, Evaluator-blinded, Parallel Group, No-treatment Controlled, Multicenter Study to Evaluate Effectiveness and Safety of Restylane® Shaype™ for Improvement of Jawline Definition in Chinese Subjects
Run by Galderma R&D · NCT07805512 · Data updated 2026-11-12
This study tests whether Restylane Shaype can improve jawline definition in adults of Chinese origin who want treatment for their jawline.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 162 (estimated) |
| Sponsor | Galderma R&D Industry-sponsored |
| Locations | 6 sites (Beijing, Beijing Municipality and 5 other locations) |
| Status | Recruiting |
| Started | September 28, 2026 |
| Main results expected | September 2027 |
| Study ends | March 2028 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT07805512 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who are of Chinese origin, 18 years or older, and seeking bilateral jawline definition treatment.
✕Probably not a fit
Individuals not seeking jawline treatment or those with contraindications to injectable HA products would be unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, evaluator-blinded, parallel-group, multicenter study conducted in China to assess the effectiveness and safety of Restylane Shaype for jawline definition. About 162 adults (18+ years, of Chinese origin) are randomized in a 2:1 ratio to receive Restylane Shaype or no treatment across six sites. The study compares outcomes between the treated and untreated groups while monitoring safety and any adverse events. It is designed to minimize bias through evaluator blinding and a no-treatment control. No data are provided on long-term follow-up or additional endpoints in the available description.
Why it matters
Potential benefit: If successful, participants could see improved jawline definition with a treatment that is evaluated for safety in this population.
How similar studies have gone: Previous studies using similar HA fillers for facial contouring have shown meaningful improvements in definition with acceptable safety profiles.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Males and non-pregnant, non-breastfeeding females of Chinese origin and aged 18 years or older. 2. Intent to receive bilateral jawline definition treatment. Exclusion Criteria: 1. Known/previous allergy or hypersensitivity to any injectable hyaluronic acid (HA) gel or to gram positive bacterial proteins. 2. Known/previous allergy or hypersensitivity to local anesthetics, e.g. lidocaine or other amide-type anesthetics. 3. Previous or present multiple allergies or severe allergies, such as manifested by anaphylaxis or angioedema, or family history of these conditions. 4. Prior surgery in the treatment area that in the Treatment investigator's opinion could interfere with the study safety and/or effectiveness assessments. 5. Any previous aesthetic procedures or implants. 6. Presence of any disease or lesions near or in the area to be treated.
Where it's running
-
Galderma Investigational Site #6601
Nanjing, Jiangsu, China Recruiting -
Galderma Investigational Site #6547
Hangzhou, Zhejiang, China Recruiting -
Galderma Investigational Site #6340
Beijing, Beijing Municipality, China Not yet recruiting -
Galderma Investigational Site #6345
Beijing, Beijing Municipality, China Not yet recruiting -
Galderma Investigational Site #6540
Beijing, Beijing Municipality, China Not yet recruiting -
Galderma Investigational Site #6347
Chengdu, Sichuan, China Not yet recruiting
Study contacts
- Study coordinator: Galderma Research & Development
- Email: Clinical.Studies@galderma.com
- Phone: +8621 23159790
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.