Impact of Theta Burst Stimulation on Autism Spectrum Disorder
Therapeutic Impacts of Theta Burst Stimulation Over Bilateral Posterior Superior Temporal Sulcus in Autism Spectrum Disorder: a Comprehensive Study Integrating Clinical Symptoms, Neuropsychological Function and MRI
This study is testing whether a new brain stimulation technique can help improve symptoms in people with autism spectrum disorder.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 8 Years to 30 Years |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT05578209 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of intermittent theta burst stimulation applied to the bilateral posterior superior temporal sulcus in individuals diagnosed with autism spectrum disorder. The approach aims to explore how this non-invasive brain stimulation technique can influence symptoms associated with autism. Participants will undergo the stimulation while being monitored for changes in their condition. The study seeks to provide insights into the therapeutic potential of this innovative intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with autism spectrum disorder who have not changed their psychiatric medications in the past month.
Not a fit: Patients with severe neurological disorders, significant brain abnormalities, or those currently pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could lead to improved management of symptoms in individuals with autism spectrum disorder.
How similar studies have performed: While the specific application of theta burst stimulation in autism is novel, similar non-invasive brain stimulation techniques have shown promise in other neurological and psychiatric conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Autism spectrum disorder, confirmed by Autism Diagnostic Observation Schedule II (CSS≧6) * No change in psychiatric drugs within one month Exclusion Criteria: * Previous or current severe neurological disorder such as epilepsy, visual or hearing impairment * Previous or current severe systemic disease such as cardiovascular disease, diabetes or infection * Previous or current severe brain injury * Implementation of metal materials such as pacemaker or medication pump * Previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse * Pregnancy * Individuals with a significant brain abnormality such as intracranial space occupied lesions * History of brain surgery or nervous system infection, such as meningitis and encephalitis * Previous febrile seizures * Concurrent use of medications which increased the risk of seizure attack. * Participate another clinical trial within one month. * Unable to complete MRI scan (claustrophobia) * Skin trauma on application site * Individuals with a large ischemic scar * Individuals suffering from multiple sclerosis * Individuals suffering from sleep deprivation during rTMS procedures * Individuals with a heavy consumption of alcohol * Individuals with a migraine headache from increased intracranial pressure
Where this trial is running
Taoyuan
- Chang Gung Memorial Hospital — Taoyuan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Hsing-Chang Ni, Dr.
- Email: alanni0918@yahoo.com.tw
- Phone: 88633281200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.