Impact of Stellate Ganglion Block on Internal Mammary Artery Function
Effect of Stellate Ganglion Block on Internal Mammary Artery Dynamics
This study is testing if a specific nerve block can improve blood flow in the internal mammary artery during heart surgery, compared to using a common medication, to help patients have better outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT05952011 on ClinicalTrials.gov |
What this trial studies
This study evaluates how a stellate ganglion block affects the flow and diameter of the internal mammary artery in patients undergoing coronary artery bypass grafting. It compares the effects of the stellate ganglion block with topical nitroglycerine on arterial dynamics, utilizing measurements like the pulsatility index and transient time flowmetry. The goal is to address complications related to conduit spasm during surgery, which can impact graft patency and patient outcomes. By exploring this regional anesthesia technique, the study aims to enhance surgical results and reduce the need for pharmacological interventions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 who are scheduled for elective coronary artery bypass graft surgery.
Not a fit: Patients over 65 years old or those with significant comorbidities such as low ejection fraction or history of strokes may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve graft patency and reduce complications during coronary artery bypass surgery.
How similar studies have performed: Previous studies have shown promising results with regional anesthesia techniques like stellate ganglion block in improving vascular outcomes, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 to 65 years. * Patients who will be slated to undergo elective coronary artery bypass graft surgery under Cardiopulmonary bypass in the Department of Cardiothoracic Surgery. Exclusion Criteria: * Patient not willing to participate in the study. * Age more than 65 years. * Ejection fraction \< 45%. * History of strokes / Transient ischaemic attacks and vertebro basilar insufficiency * History of Glaucoma. * History of allergy to local anaesthetic drugs. * Emergency coronary artery bypass graft or reoperations. * Pre-existing contralateral phrenic nerve palsy. * Patients with existing coagulopathy. * Allergy to nitroglycerin.
Where this trial is running
Cairo
- Ain shams university hospitals — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Diaaeldin DA Aboelnile, MD, Lecturer — Faculty of Medicine, Ain Shams University
- Study coordinator: Diaaeldin DA Aboelnile, MD, Lecturer
- Email: diaabadr@gmail.com
- Phone: 201018380033
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.