Impact of sleep apnea on heart health in patients with atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The POACH study aims to investigate how obstructive sleep apnea (OSA) affects cardiovascular outcomes in patients with atrial fibrillation (AF) who are at high cardiovascular risk. This prospective, observational study will recruit 1365 patients in Singapore, using a home-based sleep study to classify participants based on the presence of OSA. Patients will receive standard AF management, and follow-up assessments will occur every six months for up to two years. The study will also analyze blood samples to measure various metabolites that may provide insights into cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 22 or above
2. Known AF, including paroxysmal, persistent or permanent AF
3. High cardiovascular risk, defined as one or more of the following:

   * hypertension
   * diabetes mellitus
   * stroke
   * significant coronary artery disease (at least one stenosis of \>50% diameter in at least one major epicardial artery based on CT or conventional coronary angiography, positive stress test \[treadmill, myocardial perfusion scan, or stress echocardiography\], previous percutaneous coronary intervention, or previous coronary artery bypass surgery)
   * chronic kidney disease (excluding polycystic kidney disease) with an estimated glomerular filtration rate of \<60 ml/min/1.73m2,
   * 10-year risk of cardiovascular disease of 15% or greater on the basis of the Framingham risk score, or
   * age of 75 years or older

Exclusion Criteria:

1. Known OSA on regular CPAP treatment
2. Valvular AF (moderate/severe mitral stenosis or mechanical heart valve)
3. Permanent pacemaker implantation
4. Life expectancy less than 1 year based on concomitant medical conditions
5. Unable to give research consent
6. Pregnant or lactating women

Where it's running

• Chi-Hang Lee
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Chi-Hang R Lee, MD — National University of Singapore
• Study coordinator: Shalini Lobo, BSc
• Email: shalilb@nus.edu.sg
• Phone: 67795555

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.