Impact of root canal treatment on inflammation and healing in rheumatoid arthritis patients with dental issues
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
This study is testing whether getting root canal treatment can help reduce inflammation and improve healing in people with rheumatoid arthritis who also have dental problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 76 (estimated) |
| Sex | All |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak Academic / other |
| Locations | 1 site (Rohtak) |
| Trial ID | NCT06433232 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of root canal treatment on inflammatory markers, disease activity, and periapical healing in patients suffering from both rheumatoid arthritis and apical periodontitis. It aims to explore the connection between chronic inflammation in rheumatoid arthritis and dental infections, hypothesizing that treating apical periodontitis may improve overall inflammatory responses. The study will include patients aged 30-65 with a confirmed diagnosis of rheumatoid arthritis and specific dental conditions, while excluding those with other systemic diseases or severe periodontal issues.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30-65 with a confirmed diagnosis of rheumatoid arthritis and apical periodontitis.
Not a fit: Patients with other systemic diseases or severe periodontal conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could lead to improved management of inflammation and disease activity in rheumatoid arthritis patients.
How similar studies have performed: While there is some literature suggesting a link between dental infections and rheumatoid arthritis, this specific approach is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Age of patients 30-65 years 2.Definite diagnosis of Rheumatoid arthritis based on ACR/EULAR 2010 criteria\[28\] i.e a score of 6 or greater out of 10 from the individual scores in four domains: number and site of involved joints (range 0-5), serological abnormality (range 0-3), elevated acute-phase response (range 0-1) and symptom duration (two levels; range 0-1) 3. The periapical index (PAI) will be used to evaluate the periapical status patients with PAI \>or=3 as given by Orstavik\[29\] will be included 4. Presence of total teeth \>/= 12 Exclusion Criteria: 1. Patients with periodontitis, pocket depth and CAL\>5mm (stage 3, 4) will be excluded. 2. Pregnancy; lactation \& contraceptives 3. Patients with any other systemic disease other than Rheumatoid arthritis i.e Diabetes, HIV, Chronic Liver Disease, Chronic Kidney disease and Cardiovascular disease 5\. Conditions known to alter systemic inflammatory markers i.e orthopaedic trauma, surgery and viral infections 6. Patients with BMI \>/= 30 7. Medications (during last 3 months) known to affect systemic inflammatory markers (systemic steroids, immunosuppressants, hormone replacement therapy, contraceptives and systemic antibiotics) 8. Smoking \-
Where this trial is running
Rohtak
- Rheumatology clinic PGIMS ROHTAK — Rohtak, India (Recruiting)
Study contacts
- Study coordinator: Bhavika Bansal
- Email: bhavikabansal98@yahoo.in
- Phone: 8288984027
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.