Impact of respiratory virus infections on emergency admissions
Estimation of Prevalence of and Risk Factor for Respiratory Viruses Among Emergently Admitted Adult Patients With Respiratory Symptoms and Their Influence on Clinical Outcomes in the Settings From Rural to Urban Community Hospitals
This study is trying to see how common respiratory viruses, like RSV, are in older patients with breathing problems who come to the emergency room and how these infections impact their hospital stay.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Institute for Clinical Effectiveness, Japan Academic / other |
| Locations | 3 sites (Izumo, Shimane and 2 other locations) |
| Trial ID | NCT05913700 on ClinicalTrials.gov |
What this trial studies
This multicenter prospective registry study aims to estimate the prevalence and risk factors associated with respiratory syncytial virus (RSV) and other respiratory viral infections in patients admitted from emergency rooms. Participants aged 50 and older with respiratory symptoms are registered consecutively at three hospitals, where their medical history and clinical data are collected from electronic medical records. Nasopharyngeal swabs are taken within 24 hours of admission to test for respiratory viruses using the FilmArray 2.1 system, and serum antibodies for RSV are also obtained from consenting patients. The study seeks to understand how these infections affect hospital courses in patients with acute respiratory symptoms.
Who should consider this trial
Good fit: Ideal candidates are patients aged 50 years or older who present with respiratory symptoms and are admitted from emergency rooms.
Not a fit: Patients who are scheduled for admission, those admitted for trauma care, or those with conditions that prevent nasopharyngeal sampling will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the understanding of respiratory virus infections in older patients, leading to better management and treatment strategies.
How similar studies have performed: Other studies have shown success in understanding respiratory infections through similar observational approaches, indicating potential for valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 50 years or older * Admission from emergency room * Having at least one of following respiratory symptoms/signs for at least 24 hours and the onset date of first symptom/sign less than 7 days before admission, which meet the acute respiratory infection (ARI) case definition described below: nasal congestion, rhinorrhea, sore throat, cough, sputum, dyspnea, wheeze, crackles or rhonchi, tachypnea (\>=20 per minute), decreased saturation of oxygen (\< 95%), admission with oxygen supplementation Exclusion Criteria: * Scheduled admission * Admission for trauma care * With nasopharyngeal cavity diseases or deformity which block the nasopharyngeal sampling * Admission for end of life * Decline to participate the study by either informed consent or opt-out method
Where this trial is running
Izumo, Shimane and 2 other locations
- Shimane Prefectural Central Hospital — Izumo, Shimane, Japan (Recruiting)
- Rakuwakai Otowa Hospital — Kyoto, Japan (Recruiting)
- Nara City Hospital — Nara, Japan (Recruiting)
Study contacts
- Principal investigator: Tsukasa Nakamura, MD, PhD — Shimane Prefectural Central Hospital
- Study coordinator: Takeshi Morimoto, MD, PhD, MPH
- Email: ceo@icekyoto.org
- Phone: +81-75-778-5054
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.