Impact of physical activity and blood pressure on heart health in healthy individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the cardiovascular health of relatively healthy individuals by collecting comprehensive clinical data, advanced imaging results, and genetic information. Participants will undergo various assessments, including cardiac MRI, blood tests, and ambulatory blood pressure monitoring, to correlate these findings with adverse clinical outcomes such as myocardial infarction and stroke. The study seeks to address gaps in understanding how to interpret cardiovascular tests and improve healthcare management in Singapore.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women age 21-69 years

Exclusion Criteria:

1. Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
2. Known coronary artery disease - prior coronary revascularization
3. Known documented peripheral arterial disease
4. Previous stroke

   a. Stroke is defined as new focal neurological deficit persisting more than 24hours21.
5. More than ongoing use of 2 or more anti-hypertensive agents
6. Prior history of cancer (excludes pre-cancerous lesions)
7. Expected life expectancy less than 1 year
8. Known definite diabetes mellitus or on treatment for diabetes mellitus
9. Known autoimmune disease or genetic disease
10. Known endocrine disease on treatment
11. Psychiatric illness
12. Asthma or chronic lung disease requiring long term medications or oxygen
13. Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
14. Inability to comply with study protocol
15. Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes

Where it's running

• National Heart Centre Singapore
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Yeo Khung Keong, MBBS — National Heart Centre Singapore
• Study coordinator: Yeo Khung Keong, MBBS
• Phone: 67048963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.