Impact of Phaco Tip Location on Early Postoperative Outcomes in Cataract Surgery
Official title: The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors
Run by Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT07550907 · Data updated 2026-11-12
This observational study tests whether the position of the phacoemulsification tip during cataract surgery affects early changes in the cornea and vision in people with age-related cataracts.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 90 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | April 20, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT07550907 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 50–90 years with unilateral or bilateral age-related cataract, scheduled for phacoemulsification with IOL and meeting all ocular health criteria (LOCS III nuclear grade ≥2, pupil ≥6 mm after dilation, endothelial cell count ≥1500 cells/mm²).
✕Probably not a fit
Patients with other ocular diseases, complicated anatomy, or comorbidities may not experience a benefit from tip-position findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study involving adults aged 50 to 90 undergoing phacoemulsification with intraocular lens implantation. Intraoperative OCT will be used to document the phaco tip location (supracapsular, iris-lens diaphragm, or endocapsular) during surgery. Postoperative assessments will measure corneal changes and visual acuity at an early timepoint to explore potential associations with tip position. The study aims to identify if specific tip locations correlate with better immediate postoperative corneal status and vision. No intervention beyond standard cataract surgery and imaging is planned.
Why it matters
Potential benefit: If a link is found, surgeons may optimize phaco tip position to improve early postoperative corneal health and visual outcomes.
How similar studies have gone: Prior work has explored intraoperative variables affecting outcomes, but using intraoperative OCT to correlate phaco tip location with early corneal/visual outcomes is a novel approach with limited prior success data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 50 years and ≤ 90 years * Diagnosis of unilateral/bilateral age-related cataract * Nuclear grade ≥2 in LOCSIII classification * Scheduled for cataract phacoemulsification combined with intraocular lens implantation * Pupil size ≥6mm after dilation * Corneal endothelial cell count ≥1500 cells/mm² Exclusion Criteria: * Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease) * History of ocular trauma or surgery * Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia) * Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)
Where it's running
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Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.