Impact of oxidative stress and nutrition on cognitive decline in Alzheimer's patients
Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease
This study is testing how oxidative stress and nutrition affect memory and thinking skills in people over 55 with Alzheimer's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 350 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Pierre-Bénite) |
| Trial ID | NCT02800395 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the relationship between oxidative stress, nutrition biomarkers, and cognitive decline in patients with Alzheimer's disease. It is a monocentric, prospective study conducted at the Lyon Sud University Hospital, focusing on patients over 55 years old who present cognitive troubles, particularly memory complaints. The study aims to collect neuropsychological data and medical imaging to establish a correlation between these factors and the clinical evolution of cognitive impairments. Participants will undergo malnutrition screening and receive nutritional support as part of their care.
Who should consider this trial
Good fit: Ideal candidates are patients over 55 years old experiencing cognitive troubles, particularly memory issues, who are seen in a geriatric unit.
Not a fit: Patients unable to express their participation refusal or those under legal guardianship may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved predictive diagnostics and interventions for cognitive decline in Alzheimer's patients.
How similar studies have performed: While the specific combination of oxidative stress and nutrition biomarkers in Alzheimer's is less explored, related studies have shown promising results in understanding cognitive decline.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>55 years old patient * Patient seen during a memory consultation in geriatric Unit, Lyon Sud University Hospital * Patient or legal representative and/or person of confidence who didn't express his opposition to the clinical assay participation. * Patient registered to the general social insurance * Complementary health check scheduled at day hospital, conventional hospitalization or regular consultation. Exclusion Criteria: * Patient unable to express his participation refusal and under curatorship or unforced by the court of justice
Where this trial is running
Pierre-Bénite
- Service de Médecine Gériatrique. Groupement Hospitalier Sud. Hospices Civils de Lyon. — Pierre-Bénite, France (Recruiting)
Study contacts
- Principal investigator: Marc BONNEFOY, Pr — Hospices Civils de Lyon
- Study coordinator: Marc BONNEFOY, Pr
- Email: marc.bonnefoy@chu-lyon.fr
- Phone: (0)4 78 86 15 81
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.