Impact of Omega-3 Supplementation on Maternal Obesity and Offspring Health
Official title: The Developmental Origins of Obesity: Effect of Maternal Supplementation With Polyunsaturated Fatty Acids and Insights Into Adipose and Immune Progenitor Cells
Run by Pontificia Universidad Catolica de Chile · NCT06981676 · Data updated 2026-11-12
This study is testing if taking omega-3 supplements during pregnancy can improve the health of babies born to mothers who are obese before getting pregnant.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 160 (estimated) |
| Sponsor | Pontificia Universidad Catolica de Chile Academic / other |
| Locations | 1 site (Santiago, Santiago Metropolitan) |
| Status | Recruiting |
| Started | July 25, 2023 |
| Main results expected | March 30, 2026 |
| Study ends | March 30, 2027 |
| Registry record updated | May 21, 2025 |
| Trial ID | NCT06981676 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pregnant women with a pregestational BMI of 30 or higher, who are less than 14 weeks gestation and plan to deliver at the participating hospital.
✕Probably not a fit
Patients with preexisting diabetes, gestational diabetes, or other high-risk pregnancy conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of long-chain polyunsaturated fatty acids (LCPUFAs) supplementation during pregnancy on the health outcomes of offspring born to mothers with pregestational obesity. It aims to evaluate whether such supplementation can influence molecular markers related to adipose and immune progenitor cells in newborns, potentially affecting their risk of obesity and inflammation. The study will include women with varying body mass indices and will assess the correlation between maternal obesity, supplementation, and offspring health markers at birth.
Why it matters
Potential benefit: If successful, this study could lead to improved health outcomes for children born to obese mothers by mitigating the risks associated with maternal obesity.
How similar studies have gone: Previous studies have shown promising results regarding the impact of maternal nutrition on offspring health, suggesting that this approach may yield beneficial outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * First prenatal visit \<14 weeks gestation * Pregestational BMI between 18.5 and 24.9 for the NW groups and BMI \>30 for the PGO groups, * To have singleton pregnancy, * ≥18 years of age and plan to deliver at the Hospital Clínico UC- Christus Exclusion Criteria: * Preexisting diabetes * GDM * Preeclampsia, * Multiple gestations * Chronic cardio-respiratory disorder or neurological o genetic defects of the fetus * History of an eating disorder, food allergy, * Any high-risk pregnancy condition (MINSAL 2015)
Where it's running
-
Red Salud UC Christus Hospital
Santiago, Santiago Metropolitan, Chile Recruiting
Study contacts
- Study coordinator: Paola Casanello, Ph.D.
- Email: pcasane@uc.cl
- Phone: +56 223548119
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.