Impact of Oliceridine on Pain After Knee Surgery
A Clinical Study on the Effect of Oliceridine（TRV130） on Postoperative Rebound Pain and Early Rehabilitation Exercise After Knee Arthroscopy
This study looks at how well Oliceridine and nerve blocks help manage pain after knee surgery and what factors might affect recovery for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 320 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | The First Affiliated Hospital of Xiamen University Academic / other |
| Locations | 1 site (Xiamen, Fujian) |
| Trial ID | NCT06382896 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify risk factors for postoperative pain outbreaks in patients undergoing arthroscopic knee surgery who receive Oliceridine and nerve block. It will evaluate the timing and duration of pain after surgery, along with factors such as age, gender, and surgical history. A total of 320 patients will be monitored to gather data on their pain levels and recovery experiences. The study seeks to enhance understanding of pain management in this surgical context.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 with a BMI of 18-30 who are undergoing arthroscopic knee surgery.
Not a fit: Patients with severe trauma, psychiatric conditions, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve pain management strategies for patients recovering from knee surgery.
How similar studies have performed: While similar studies have explored postoperative pain management, the specific focus on Oliceridine in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-70 years old;2. Body mass index (BMI) 18-30kg /m2;3. American Society of Anesthesiologists (ASA) Grade I to II;4. Hospital stay \>24h. Exclusion Criteria: 1. Patients who cannot understand the numerical rating scale score and give feedback;2. Known allergy to the drug in the study;3. Infection of puncture site with nerve block;4. Oral analgesics for more than 2 weeks before surgery;5. Long-term use of glucocorticoids;6. Simultaneous surgery on both limbs;7. A psychopath;8. Severe compound trauma;9. Pregnant and lactating women.
Where this trial is running
Xiamen, Fujian
- First Affiliated Hospital of Xiamen University — Xiamen, Fujian, China (Recruiting)
Study contacts
- Study coordinator: Bin Yang, doctor
- Email: yangbin4332@outlook.com
- Phone: 13859986036
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.