Impact of muscle loss on knee surgery outcomes
Effect of Sarcopenia on Clinical Outcome of Total Knee Arthroplasty
This study looks at how muscle loss affects recovery and success after knee surgery in women over 60 with knee arthritis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 60 Years and up |
| Sex | Female |
| Sponsor | Gangnam Severance Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT06136039 on ClinicalTrials.gov |
What this trial studies
This study investigates the effect of sarcopenia, or muscle loss, on the clinical outcomes of total knee arthroplasty (TKA) in elderly women suffering from knee osteoarthritis. By comparing outcomes between patients with sarcopenia and those with normal muscle mass, the research aims to identify how muscle health influences recovery and surgical success. The study focuses on a specific demographic, targeting women aged 60 and older who are undergoing TKA, to fill a gap in orthopedic research regarding sarcopenia. The findings could lead to improved surgical strategies and rehabilitation protocols for this population.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 60 or older who are scheduled for total knee arthroplasty due to degenerative osteoarthritis.
Not a fit: Patients who are male, under 60 years of age, or have certain joint diseases or conditions that prevent muscle strength testing will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance recovery and outcomes for elderly women undergoing knee surgery by addressing the impact of muscle health.
How similar studies have performed: While research on sarcopenia has gained traction in various fields, this specific investigation into its effects on orthopedic outcomes is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * A woman aged 60 or older who is undergoing TKA due to degenerative osteoarthritis of the knee joint at the our institution. Exclusion Criteria: 1. Male 2. Under 60 years of age 3. Patients with a history of rheumatoid arthritis, traumatic joint disease, and post-infection joint disease 4. Patients who cannot undergo tests for muscle weakness diagnosis A. Patients unable to walk B. Patients unable to stand alone due to conditions like cerebral palsy or brain disorders C. Patients unable to use muscle strength 5. Patients considered inappropriate for recruitment in this study based on the judgment of the research team.
Where this trial is running
Seoul
- GangnamSeverance Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Study coordinator: Byungwoo Cho
- Email: gsirb@yuhs.ac
- Phone: 82-2-2019-3419
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.