Impact of MASLD on frailty, cognition, and quality of life by gender

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study exploring how MASLD-related frailty presents and evolves in men and women. Researchers will examine associations between frailty and clinical, functional, hormonal, and social parameters. The study collects periodic assessments to understand gender-specific differences in prevalence and characteristics. No interventions are being tested; the focus is on describing patterns and potential relationships. The lead site is Hospital de la Santa Creu i Sant Pau in Barcelona, with collaboration across the same institution.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients will be included who are able to provide informed consent and actively participate in periodic assessments.

Exclusion Criteria:

* Risky alcohol consumption:

\> 30 g/day in men and \> 20 g/day in women. AUDIT score: \> 7 points in men, \> 5 in women.

* Other liver diseases (viral hepatitis, autoimmune hepatitis, etc.).
* Advanced neurodegenerative diseases or severe psychiatric disorders.
* Severe comorbidities or treatments that, in the researchers' judgment, may affect frailty and quality of life more than metabolic syndrome and liver disease.

Where it's running

• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Recruiting
• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Not yet recruiting

Study contacts

• Principal investigator: Eva Roman — Institut de Recerca IR Sant Pau
• Study coordinator: Eva Román, Digestive Pathology Nurse
• Email: ERoman@santpau.cat
• Phone: 0034630818580

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.