Impact of Magnesium Sulfate on Nerve Monitoring During Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of magnesium sulfate on intraoperative neurophysiological monitoring (IONM) during spine and cranial surgeries. It is a prospective, double-blind, randomized placebo-controlled trial that aims to assess how magnesium sulfate influences the amplitude and latency of somatosensory and motor evoked potentials. By comparing the effects of magnesium sulfate to a placebo, the study seeks to provide insights into optimizing pain management and nerve monitoring during complex surgical procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria.

* Patients aged 18 to 80 years
* Belonging to American Society of Anesthesiologists physical status (ASA) I, II
* Undergoing elective spine or cranial surgery where intraoperative neuromonitoring including short latency somatosensory evoked potentials (SSEP or SEP) and transcranial electrical muscle motor evoked potentials recording from muscles (TceMEP or TcMEP or mMEP or MEP) is planned.

Exclusion Criteria:

* Magnesium use within the last 2 days, either intravenous or oral supplements.
* Patients with known electrolyte imbalances (Sodium \<135 or \>145 mmol/L OR Potassium \< 3.5 or \> 5.0 mmol/L, Magnesium \>1.2 mmol/L.
* Severe cardiac or cardiac conduction disorders.
* Severe pulmonary disease.
* Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.
* Severe Renal disease - serum creatinine of \> 2 mg/dl.
* Pregnant or breastfeeding patients.
* Unable to obtain adequate baseline SSEPs and MEPs.

Where it's running

• Loma linda University Medical Center
  Loma Linda, California, United States Recruiting

Study contacts

• Principal investigator: Rashmi Vandse, MD — Loma Linda University
• Study coordinator: Rashmi Vandse, MD
• Email: rvandse@llu.edu
• Phone: 9095584000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.