Impact of magnesium levels on the effectiveness of epidural steroid injections for back pain
Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid
This study is trying to see if the amount of magnesium in the blood affects how well epidural steroid injections work for people with back pain from a herniated disc.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT06551792 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how serum magnesium levels influence the success of transforaminal epidural steroid injections (TFESE) in patients suffering from radicular pain due to disc herniation. The research involves a retrospective analysis of patient records from the Algology Department at Kanuni Sultan Süleyman Training and Research Hospital, focusing on patients who underwent TFESE between January 2022 and January 2024. Key metrics such as pain severity and functionality will be assessed using the Numeric Rating Scale and Oswestry Disability Index at baseline and follow-up intervals. The study aims to correlate magnesium levels with treatment outcomes to better understand factors affecting TFESE efficacy.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with paracentral/subarticular protruded disc herniation who are undergoing TFESE.
Not a fit: Patients with conditions affecting magnesium levels, such as metabolic diseases or those taking supplements, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify patients who are more likely to benefit from TFESE based on their magnesium levels, potentially improving pain management strategies.
How similar studies have performed: While studies on TFESE are common, the specific focus on serum magnesium levels is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Exclusion Criteria: * Patients whose medical analgesic treatment was changed during their three-month follow-up; * Those with fibromyalgia; * Those with metabolic diseases (chronic renal failure, spondyloarthropathies, diabetes, hypo/hyperthyroidism, etc.) that may affect serum magnesium level; * Those with a history of lumbar surgery; * those taking magnesium or calcium supplements; * Those with malignancy or obesity; * Those with psychiatric illness; * Those without lumbar MRI; Patients whose clinical, physical examination and laboratory data cannot be accessed
Where this trial is running
Istanbul
- Kanuni Sultan Süleyman Training and Research Hospital — Istanbul, Turkey (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.