Impact of liver surgery techniques on heart injury after non-cardiac surgeries
Differential Impact of Pringle Occlusion vs. Portal Vein Occlusion-Induced Liver Ischaemia-Reperfusion Injury on Myocardial Injury Following Noncardiac Surgeries.
This study is testing how different liver surgery methods might affect heart injury in older patients or those with heart risks after they have major surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 45 Years to 85 Years |
| Sex | All |
| Sponsor | Beijing Tsinghua Chang Gung Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06895798 on ClinicalTrials.gov |
What this trial studies
This observational cohort study investigates how different liver surgery techniques, specifically Pringle occlusion and portal vein occlusion, affect the incidence of myocardial injury after non-cardiac surgery. It will enroll patients aged 65 and older, or those aged 45 and older with cardiovascular risk factors, who are undergoing major hepato-biliary surgery. Clinical data and postoperative outcomes will be collected and analyzed to identify risk factors for myocardial injury. The study aims to provide insights into the mechanisms behind myocardial injury and improve early recognition and prevention strategies.
Who should consider this trial
Good fit: Ideal candidates are patients aged 65 and older, or those aged 45 and older with cardiovascular risk factors, scheduled for elective major hepato-biliary surgery.
Not a fit: Patients undergoing emergency surgery or those with severe organ dysfunction or active infectious diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing myocardial injury in patients undergoing major surgeries.
How similar studies have performed: While the specific approach of comparing Pringle and portal vein occlusion is novel, studies on myocardial injury after non-cardiac surgeries have shown varying degrees of success in understanding risk factors.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 65 years, or ≥ 45 years with cardiovascular risk factors (especially known cardiovascular disease). * Undergoing elective major hepatopancreatobiliary surgery under general anesthesia. * ASA physical status II-III. * Provide written informed consent to participate in the study (applicable to the prospective cohort). Exclusion Criteria: * Emergency surgery * Preoperative diagnosis of myocardial infarction or unstable angina * Severe hepatic insufficiency (Child-Pugh class C) * Concomitant severe organ dysfunction (e.g., renal failure, respiratory failure) * Concomitant active infectious disease
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Zhifeng Gao, MD
- Email: btchgzf@hotmail.com
- Phone: +8615801249466
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.