Clinical trial Recruiting at 1 site Observational Ages 18 to 80

Impact of hsCRP on heart disease patients after PCI

Official title: The Prognosis of Patients After Coronary Intervention (PCI) : a Multi-center Prospective Study in China

Run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · NCT05614050 · Data updated 2026-11-12

This study is trying to see if measuring a specific protein in the blood can help predict how well heart disease patients do after a procedure to open blocked arteries.

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Quick facts

Study typeObservational
Ages18 Years to 80 Years
SexAll
Enrollment2400 (estimated)
SponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Wuhan, Hubei)
StatusRecruiting
StartedNovember 1, 2022
Main results expectedNovember 1, 2027
Study endsNovember 1, 2027
Registry record updatedNovember 9, 2026
Trial IDNCT05614050 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include hospitalized patients aged 18 to 80 with coronary heart disease who are undergoing PCI.

Probably not a fit

Patients with acute or chronic infections, immune diseases, or those on specific long-term medications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of high-sensitivity C-reactive protein (hsCRP) in predicting the prognosis of patients with coronary artery disease (CAD) who have undergone percutaneous coronary interventions (PCI). The study will recruit patients from 14 hospitals across China and will monitor changes in hsCRP levels over one year to assess their correlation with major adverse cardiovascular and cerebrovascular events (MACCE). By understanding the residual inflammation risk (RIR) associated with hsCRP, the study seeks to provide insights into improving patient outcomes post-PCI.

Why it matters

Potential benefit: If successful, this study could enhance the management and treatment strategies for patients with CAD, potentially reducing the risk of serious cardiovascular events.

How similar studies have gone: Previous studies in Western populations have shown a correlation between hsCRP levels and cardiovascular risk, but this specific approach in the Chinese population is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants who understand and sign the informed consent voluntarily;
* Age ≥ 18 years old and ≤ 80 years old, regardless of sex;
* The hospitalized patients with coronary heart disease undergoing PCI;
* Complete all planned PCI during hospitalization.

Exclusion Criteria:

* Acute, chronic or recurrent infectious diseases;
* Immune diseases or immune-related diseases;
* Long-term use of non-steroidal anti-inflammatory drugs, hormones, immunomodulatory and chemotherapy drugs;
* Pregnant women, lactating women or women of childbearing age who do not use effective contraceptive measures;
* The researchers determined that other conditions in which the patient was not suitable to participate in the clinical trial.

Where it's running

  • Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Wuhan, Hubei, China
    Recruiting

Study contacts

  • Principal investigator: Xiang Cheng, Doctor — Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Study coordinator: Miao Yu
  • Email: yumiaodavid@126.com
  • Phone: +862785726009

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.