Impact of haploidentical stem cell donation on donor psychology
Official title: Psychological Impact of Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation on Donors
Run by Assistance Publique - Hôpitaux de Paris · NCT06089850 · Data updated 2026-11-12
This study is trying to see how donating stem cells to a family member affects the mental health of adult donors, like parents or children, by looking at their anxiety and depression levels after the donation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | January 22, 2024 |
| Main results expected | January 2026 |
| Study ends | January 2028 |
| Registry record updated | April 2, 2025 |
| Trial ID | NCT06089850 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult haploidentical stem cell donors who are either parents or children of the transplant recipients and reside in mainland France.
✕Probably not a fit
Patients who do not have a familial relationship with the transplant recipient or those who cannot communicate in French may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study explores the psychological effects of haploidentical hematopoietic stem cell transplantation on adult donors who are either parents or children of the recipients. It employs a prospective, bicentric approach to assess changes in anxiety and depression levels at multiple time points post-donation using validated questionnaires. The aim is to understand the psychosocial implications of intra-family donations, which have become more common due to the rise of haploidentical transplants. By evaluating the mental health of donors, the study seeks to address the clinical and ethical concerns surrounding this type of transplantation.
Why it matters
Potential benefit: If successful, this study could provide insights into the psychological support needed for donors, improving their mental health outcomes.
How similar studies have gone: While the psychological impact of organ donation has been studied, this specific focus on haploidentical stem cell donors is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Identical haplo CSH donors ascending (parents) or descending (children) * Major identical haplo HSC donors * Haplo-identical HSC donors living in mainland France and cared for in the centers participating in the study * Haplo-identical HSC donors benefiting from Social Security System. * Haplo-identical HSC donors who have signed the consent form * \- Ability to read and write in French Exclusion Criteria: \- Insufficient understanding of the French language
Where it's running
-
Service D'hématologie Clinique et thérapie cellulaire - Hôpital St Antoine
Paris, France Recruiting
Study contacts
- Principal investigator: Eolia Brissot — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Eolia Brissot
- Email: eolia.brissot@aphp.fr
- Phone: 01 49 28 34 38
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.