Impact of exercise on gut microbiota and type 2 diabetes
The Effects of Regular Exercise on Gut Microbiota Composition in Individuals with Type 2 Diabetes
This study tests if regular exercise can improve gut health and help people aged 45 to 65 who are moving from normal blood sugar levels to prediabetes or type 2 diabetes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 45 Years to 65 Years |
| Sex | All |
| Sponsor | University of Thessaly Academic / other |
| Locations | 1 site (Trikala) |
| Trial ID | NCT06562842 on ClinicalTrials.gov |
What this trial studies
This randomized, controlled study investigates how regular exercise affects gut microbiota composition, inflammation, and insulin sensitivity in individuals transitioning from normal glucose tolerance to prediabetes and type 2 diabetes. Participants aged 45 to 65 will be assigned to either a 12-week exercise program or remain sedentary for 16 weeks. The study will assess the differences in metabolic health and gut microbiota between those who exercise and those who do not, across three groups: normal glucose tolerance, prediabetes, and type 2 diabetes. The goal is to understand the role of exercise in preventing and managing type 2 diabetes.
Who should consider this trial
Good fit: Ideal candidates are sedentary individuals aged 45 to 65 who are at risk of developing type 2 diabetes.
Not a fit: Patients who are physically active or have chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how exercise can improve metabolic health and gut microbiota, potentially preventing or managing type 2 diabetes.
How similar studies have performed: Other studies have shown promising results regarding the benefits of exercise on metabolic health, but this specific approach focusing on gut microbiota is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 45 and 65 years old * Sedentary lifestyle or insufficient daily physical activity according to guidelines for T2D * Abstinence of anti-inflammatory drugs and/or antibiotics and/or dietary supplements that could affect GM composition before the study (\>3 months) * No other chronic diseases and/or musculoskeletal injuries (\>6 months) Exclusion Criteria: * Age \<45 years or \>65 years * Physically active individuals * Consumption of anti-inflammatory drugs and/or antibiotics and/or dietary supplements that could affect GM composition before the study (\<3 months) * Other chronic diseases ot recent history of musculoskeletal injury (\<6 months)
Where this trial is running
Trikala
- Department of Physical Education and Sport Science, Uninersity of Thessaly — Trikala, Greece (Recruiting)
Study contacts
- Principal investigator: Chariklia K. Deli, PhD — University of Thessaly
- Study coordinator: Chariklia K. Deli, PhD
- Email: delixar@pe.uth.gr
- Phone: +302431047011
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.