Impact of exercise on gut microbiota and type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled study investigates how regular exercise affects gut microbiota composition, inflammation, and insulin sensitivity in individuals transitioning from normal glucose tolerance to prediabetes and type 2 diabetes. Participants aged 45 to 65 will be assigned to either a 12-week exercise program or remain sedentary for 16 weeks. The study will assess the differences in metabolic health and gut microbiota between those who exercise and those who do not, across three groups: normal glucose tolerance, prediabetes, and type 2 diabetes. The goal is to understand the role of exercise in preventing and managing type 2 diabetes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 45 and 65 years old
* Sedentary lifestyle or insufficient daily physical activity according to guidelines for T2D
* Abstinence of anti-inflammatory drugs and/or antibiotics and/or dietary supplements that could affect GM composition before the study (\>3 months)
* No other chronic diseases and/or musculoskeletal injuries (\>6 months)

Exclusion Criteria:

* Age \<45 years or \>65 years
* Physically active individuals
* Consumption of anti-inflammatory drugs and/or antibiotics and/or dietary supplements that could affect GM composition before the study (\<3 months)
* Other chronic diseases ot recent history of musculoskeletal injury (\<6 months)

Where it's running

• Department of Physical Education and Sport Science, Uninersity of Thessaly
  Trikala, Greece Recruiting

Study contacts

• Principal investigator: Chariklia K. Deli, PhD — University of Thessaly
• Study coordinator: Chariklia K. Deli, PhD
• Email: delixar@pe.uth.gr
• Phone: +302431047011

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.