Impact of endometrial compaction on assisted reproductive technology outcomes
The Impact of Endometrial Compaction on Assisted Reproductive Technology Outcome
This study is testing whether the lack of endometrial compaction on the day embryos are transferred affects the success of fertility treatments in women.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 356 (estimated) |
| Ages | 18 Years to 37 Years |
| Sex | Female |
| Sponsor | Zagazig University Government |
| Locations | 1 site (Zagazig) |
| Trial ID | NCT04721522 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how the absence of endometrial compaction on the day of embryo transfer affects the success rates of assisted reproductive technology (ART). It focuses on the critical interaction between the blastocyst and the endometrium, which is essential for successful implantation. The study employs non-invasive methods such as ultrasound imaging and blood sampling to assess endometrial receptivity in women undergoing fresh ICSI cycles. By evaluating parameters like endometrial thickness and pattern, the study aims to identify factors that contribute to implantation failure.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 37 undergoing fresh ICSI cycles with at least one good-quality embryo available for transfer.
Not a fit: Patients with congenital uterine abnormalities, chronic diseases unsuitable for pregnancy, or those outside the age range of 18 to 37 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the success rates of ART by enhancing understanding of endometrial receptivity.
How similar studies have performed: Previous studies have indicated that assessing endometrial receptivity through ultrasound can significantly impact ART outcomes, suggesting that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All women should have the following: Aged from 18 - 37 years old. Undergoing fresh ICSI cycles. A normal uterus with no anomalies or pathologies. At least one good-quality embryo/blastocyst available for transfer (3 BB and more according to Gardner and Schoolcraft grading system). Easy mockup embryo transfer (i.e. the catheter is smoothly inserted without touching the fundus, no cervix tenaculum is used and the catheter is clean of blood). Exclusion Criteria: - Younger than 18 or older than 37 years old. Congenital uterine abnormality or pathology. Presence of a hydrosalpinx. Chronic diseases which are not suitable for pregnancy. ICSI cycles with fresh or frozen TESE samples.
Where this trial is running
Zagazig
- Zagazig university — Zagazig, Egypt (Recruiting)
Study contacts
- Principal investigator: rana nabil, Msc — zagazig university hospital
- Study coordinator: eman ElGindy, MD, PhD
- Email: eman_elgindy2013@hotmail.com
- Phone: 01227491143
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.