Impact of Ejaculation Timing on IVF Outcomes
The Effect of Reducing Ejaculation Abstinence Time on Assisted Reproductive Technology Outcomes: a Prospective Randomized Controlled Study
NA · The First Hospital of Jilin University · NCT06410417
This study is testing if having less time between ejaculation and egg retrieval can help improve the success of IVF treatments for couples trying to conceive.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | All |
| Sponsor | The First Hospital of Jilin University (other) |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Chang chun, Jilin) |
| Trial ID | NCT06410417 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to determine whether reducing the ejaculation abstinence time can enhance the outcomes of assisted reproductive technology, specifically in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Participants will be divided into two groups: one group will abstain from ejaculation for 3-7 days, while the experimental group will ejaculate within 48 hours before egg retrieval. The study will evaluate clinical pregnancy rates, embryo quality, and the effects on pregnancy loss and live birth rates. The findings could provide insights into optimal practices for improving IVF success rates.
Who should consider this trial
Good fit: Ideal candidates are couples aged 20 to 45 with a normal male ejaculation function who are seeking assisted reproductive technology.
Not a fit: Patients with serious infections, major physical diseases, or conditions affecting semen quality may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved clinical pregnancy rates and embryo quality for couples undergoing assisted reproductive technology.
How similar studies have performed: While the specific approach of reducing ejaculation abstinence time is less commonly studied, related research has shown varying results in optimizing IVF outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The couple is between 20 and 45 years old, and the woman's body mass index is greater than 18.5 and less than 30kg/m2. * Meet the indications of assisted reproductive technology, agree to use assisted reproductive technology to assist pregnancy and have entered the process. * The male has normal ejaculation function and plans to provide a semen sample by masturbation method on the day of egg retrieval. Exclusion Criteria: * Couples with serious infections and major physical diseases, such as HIV. * The use of testicular sperm for intracytoplasmic sperm injection, such as the azoospermia. * The use of frozen sperm for assisted reproductive technology. * Endometriosis, repeated implantation failure, etc. * There are clear factors affecting semen parameters within 3 months before sperm extraction, including high temperature, contact with chemicals，radiation or drugs that affect sperm, etc.;Previous orchitis/epididymitis, cryptorchidism, receiving radiotherapy and chemotherapy treatment
Where this trial is running
Chang chun, Jilin
- the first hospital of Jilin University — Chang chun, Jilin, China (RECRUITING)
Study contacts
- Principal investigator: Yueying Zhu, Master — The First Hospital of Jilin University
- Study coordinator: Yueying Zhu, Master
- Email: zhuyueying1974@jlu.edu.cn
- Phone: 13504308455
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Fertilization in Vitro, in vitro fertilization, intracytoplasmic sperm injection, Abstinence time, Clinical pregnancy rate, Embryo quality