Impact of early enteral nutrition on recovery in ovarian cancer patients
Clinical Study on the Effect of Early Enteral Nutrition Implemented by Placing Nasojejunal Tube During Ovarian Cancer Surgery on Patients' Postoperative Recovery and Prognosis
This study is testing if feeding ovarian cancer patients through a special tube right after surgery helps them recover better than the usual feeding method.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | Female |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT06236958 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the effects of enteral nutrition delivered via a nasojejunal tube against traditional parenteral nutrition in patients undergoing tumor cytoreduction for advanced epithelial ovarian cancer. The study focuses on the early postoperative period, where nutritional support is critical for recovery and prognosis. By placing a nasojejunal tube during surgery, the researchers hope to enhance recovery, reduce complications, and improve survival outcomes for these patients. The study is conducted at a single center and involves a prospective observational design.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 75 with advanced epithelial ovarian cancer undergoing tumor cytoreductive surgery.
Not a fit: Patients with intestinal obstruction, severe infections, or other acute abdominal conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve postoperative recovery and survival rates for patients with advanced ovarian cancer.
How similar studies have performed: While the use of enteral nutrition in this specific context is novel, similar studies have shown positive outcomes with enteral nutrition in other surgical populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * (1) The age is more than 18 years old and not more than 75 years old; (2) Ovarian cancer patients who are clearly diagnosed as epithelial ovarian cancer by pathological examination, whose tumors involve organs other than the pelvis as determined by preoperative imaging and intraoperative visual judgment, and who are at FIGO stage III or IV, and who undergo tumor cytoreductive surgery; (3) Patients without contraindication to nasoenteric tube placement and enteral nutrition; (4) Patients and their families were informed of the significance of the early use of enteral nutrition, precautions, adverse reactions, etc., before the operation, and they gave informed consent to this study and signed the informed consent; (5) Patients who received treatment in our hospital with complete clinical data. Exclusion Criteria: * (1) Patients with intestinal obstruction, severe intestinal infection, severe diarrhea, and acute abdomen right before surgery; (2) Patients with esophagogastric fundal varices and active gastrointestinal bleeding right before surgery; (3) Patients who undergo surgery to simultaneously resect the intestinal canal in the area more than 15cm distal to the ligament of Traitz; (4) Patients with severe cardiac, hepatic, and renal failure; (5) Patients with severe rhinitis, nasal mucous membrane damage, bleeding; (6) Patients with other malignant tumors combined within 3 months before surgery; (7) Metastatic ovarian cancer; (8) Those with missing clinical information; (9) Those with known hypersensitivity to enteral nutrition preparations.
Where this trial is running
Nanjing, Jiangsu
- The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) — Nanjing, Jiangsu, China (Recruiting)
Study contacts
- Principal investigator: Luo Chengyan, Doctor — The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)
- Study coordinator: Luo Chengyan, Doctor
- Email: betteryuan66@163.com
- Phone: 13914751661
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.