Impact of donor gene mutations on outcomes after stem cell transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of donor clonal hematopoiesis on the long-term outcomes of recipients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). It involves both prospective and retrospective data collection from donors and recipients at Queen Mary Hospital in Hong Kong. The study will analyze genetic profiles through next-generation sequencing to determine the association between donor gene mutations and recipient outcomes, including graft function and disease relapse. Data will be collected at various time points, including before and after transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult aged 18 year or above
2. Donor and recipient of allo-HSCT
3. In prospective and partial prospective/retrospective case, subjects who have provided a signed written informed consent. In retrospective case, subjects who had provided a previously signed written informed consent on:

   1. voluntary provision of clinical data, and
   2. voluntary provision of archived/remaining specimens for genetic analysis, and
   3. authorizing storage and usage of archived/remaining specimens for any further analysis

Exclusion Criteria:

1\. Autologous peripheral blood stem cells or bone marrow stem cell donors for autologous HSCT

Where it's running

• The University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Harinder Gill, MD — The University of Hong Kong
• Study coordinator: Harinder Gill, MD
• Email: gillhsh@hku.hk
• Phone: +852 22554542

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.