Impact of Diabetes on Cognitive Function in Hemodialysis Patients
Changes of Cognitive Function and Brain Magnetic Resonance in Maintenance Hemodialysis Patients With Diabetes Mellitus
This study looks at how diabetes affects thinking and brain health in people with kidney disease who are on hemodialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Locations | 2 sites (Beijing, Beijing and 1 other locations) |
| Trial ID | NCT05953818 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the cognitive function and brain changes in patients undergoing maintenance hemodialysis who also have diabetes mellitus. It aims to understand the relationship between cognitive impairment and the effects of chronic kidney disease and diabetes on brain health. Participants will undergo cognitive assessments using the Chinese version of the Montreal Cognitive Assessment Scale (MoCA) and high-resolution brain magnetic resonance imaging. The study seeks to clarify the mechanisms behind cognitive dysfunction in this patient population.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who have been on maintenance hemodialysis for at least three months and have a primary education or higher.
Not a fit: Patients with known nervous system diseases, severe mental illness, or other serious physical conditions affecting cognitive function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive impairment in patients with diabetes undergoing hemodialysis.
How similar studies have performed: While cognitive impairment in hemodialysis patients has been studied, this specific focus on the interplay with diabetes is less explored, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age must be greater than 18 years old * Receiving primary or higher education * Dialysis 3 times a week, 4 hours per session, with dialysis time greater than 3 months * Voluntarily participate in this study and sign an informed consent form. Exclusion Criteria:Participants who meet any of the following conditions are excluded: * The patient has any known Nervous system disease, such as dementia or Parkinson's disease. * Have a history of mental illness, such as depression or schizophrenia. * Suffering from visual, hearing, and language impairments, unable to cooperate with cognitive function assessment * In the past 3 months, he has been unconscious, unconscious or other stress states due to infection, acute cardio cerebral Vascular disease. * Suffering from severe liver damage or other serious physical diseases that may affect cognitive function. * Have Alcohol dependence or psychotropic substance abuse, and currently use drugs that affect cognitive function or renal function. * Patients with metallic substances in their bodies cannot pass magnetic resonance imaging (MRI) examination.
Where this trial is running
Beijing, Beijing and 1 other locations
- Beijing Friendship hospital — Beijing, Beijing, China (Recruiting)
- Ethics Committee of Beijing Shunyi District Hosipital. — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Jia Wang — student
- Study coordinator: WenHu LIU
- Email: wenhuliu@mail.ccmu.edu.cn
- Phone: 15011393263
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.