Impact of CRRT patterns on calcium levels in patients using citrate anticoagulants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study investigates how different continuous renal replacement therapy (CRRT) methods, specifically veno-venous hemofiltration (CVVH) and continuous veno-venous hemodialysis (CVVHD), affect ionized calcium concentrations in patients undergoing regional citrate anticoagulation. Patients will be randomly assigned to one of the two CRRT methods and will switch to the alternative method in subsequent sessions. Key measurements will include pre-filter and post-filter ionized calcium levels, as well as other electrolyte and citrate dose data collected throughout the treatment. The study aims to clarify the relationship between CRRT patterns and calcium levels, which is crucial for patient safety and treatment efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years old;
2. Receiving citrate anticoagulation;
3. Obtain Informed consent from patients or next of kin.

Exclusion Criteria:

1. Pregnant or lactating women;
2. Allergic to citrate anticoagulants;
3. Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);
4. Hypoxemia (PaO2 \< 60 mmHg);
5. Inadequate tissue perfusion (blood pressure \< 90/60 mmHg despite high doses of vasoactive agents);
6. Hyperlactatemia (lactate\> 4 mmol/L);
7. Hypernatremia;
8. Estimated length of hospital stay \< 48h;
9. Participated in other studies.

Where it's running

• Fujian Provincial Hospital
  Fuzhou, Fujian, China Recruiting

Study contacts

• Principal investigator: Han Chen, Ph.D., M.D. — Fujian Provincial Hospital
• Study coordinator: Han Chen, Ph.D., M.D.
• Email: hanchen.cn@icloud.com
• Phone: +86 591 88217010

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.