Impact of comorbidities after radical cystectomy using an AI-based predictive method
Official title: Evaluation of the Impact of COMORBIDities on Morbidity and Mortality After Radical Cystectomy for Cancer Using a Predictive Method With Artificial Intelligence
Run by Centre Hospitalier Universitaire, Amiens · NCT05204186 · Data updated 2026-11-12
This study tests whether an AI-based method can help predict outcomes for bladder cancer patients undergoing radical cystectomy, focusing on how comorbidities influence treatment choices and survival.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens, Picardie) |
| Status | Recruiting |
| Started | August 12, 2021 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT05204186 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older who have undergone radical cystectomy for bladder cancer.
✕Probably not a fit
Patients without sufficient data on comorbidities or with distant metastases at baseline may derive limited or no benefit from the predictive approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study uses a predictive approach that combines artificial intelligence and clinical data to understand how non-cancer health conditions affect decisions at the urologic oncology team and patient outcomes after radical cystectomy for bladder cancer. The project aims to quantify how comorbidities and provider judgment influence guideline adherence and survival, using methods like cumulative incidence to account for competing mortality risks. Data are analyzed to identify patients at higher risk of early death and to inform more tailored treatment guidelines. The study is centered at CHU Amiens with collaboration from local oncology teams, evaluating real-world practice patterns and outcomes.
Why it matters
Potential benefit: If successful, the approach could improve risk stratification and guide more personalized treatment decisions for bladder cancer patients undergoing surgery.
How similar studies have gone: Previous work with AI and comorbidity data in urologic oncology has shown promise, but this exact predictive method in radical cystectomy care is an emerging area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years and older * Patient treated by radical cystectomy for bladder cancer Exclusion Criteria: * Computed tomography/magnetic resonance evidence of distant metastases.
Where it's running
-
CHU Amiens Picardie
Amiens, Picardie, France Recruiting
Study contacts
- Study coordinator: Fabien SAINT, Pr
- Email: saint-fabien@chu-amiens.fr
- Phone: 03 22 45 59 52
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.