Impact of Cesarean Section Scar on Fertility Treatments
Cesarean Section Scar Niche: The Impact on Assisted Reproductive Technology Outcome
This study is testing how a cesarean section scar might affect the success of fertility treatments in women who are having trouble getting pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 266 (estimated) |
| Ages | 18 Years to 37 Years |
| Sex | Female |
| Sponsor | Zagazig University Government |
| Locations | 1 site (Zagazig) |
| Trial ID | NCT05966558 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how the presence of a cesarean section niche affects the outcomes of assisted reproductive technology (ART) in women experiencing secondary infertility. The niche, characterized by an indentation in the uterine wall at the cesarean scar site, may lead to complications such as abnormal bleeding and reduced chances of embryo implantation. The study aims to clarify the relationship between the niche's characteristics and ART success rates, particularly focusing on embryo transfer procedures. Participants will include women aged 18-37 undergoing fresh ICSI cycles with specific eligibility criteria.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-37 with a normal uterus undergoing fresh ICSI cycles and having at least one good-quality embryo for transfer.
Not a fit: Patients with congenital uterine abnormalities, chronic diseases unsuitable for pregnancy, or those outside the age range of 18-37 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve ART outcomes for women with cesarean section niches by informing better clinical practices.
How similar studies have performed: While the impact of cesarean section niches on ART outcomes is not extensively studied, similar investigations into uterine abnormalities have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All women should have the following: * Aged from 18 - 37 years old. * Undergoing fresh ICSI cycles. * A normal uterus with no anomalies or pathologies. * At least one good-quality embryo/blastocyst available for transfer (3 BB and more according to Gardner and Schoolcraft grading system). * Easy mockup embryo transfer (i.e. the catheter is smoothly inserted without touching the fundus, no cervix tenaculum is used and the catheter is clean of blood). Exclusion Criteria: * Younger than 18 or older than 37 years old. * Congenital uterine abnormality or pathology. * Presence of a hydrosalpinx. * Chronic diseases which are not suitable for pregnancy. * ICSI cycles with fresh or frozen TESE samples.
Where this trial is running
Zagazig
- Zagazig university — Zagazig, Egypt (Recruiting)
Study contacts
- Study coordinator: eman elgingy, M.D
- Email: eman_elgindy2013@hotmail.com
- Phone: +20 122 749 1143
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.