Impact of Carotid Artery Stenting on Brain Blood Flow and Cognitive Function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of carotid artery stenting on cerebral blood oxygenation and neurocognitive function in patients with severe carotid artery stenosis. Patients aged 35-80 with confirmed high-grade stenosis will undergo cognitive assessments and functional near-infrared spectroscopy (fNIRS) before and after the stenting procedure, with follow-up evaluations at six months. The study aims to determine whether revascularization can improve blood flow to the brain and enhance cognitive performance. Cognitive tests such as the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) will be utilized to measure changes in cognitive function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 35-80 years old
2. Severe carotid stenosis (MRA or CTA confirmed stenosis rate of 70% - 99%, NASCET standard)
3. Asymptomatic or mild stroke (NIHSS ≤ 3) or TIA
4. Agree to participate in the clinical trial and sign the informed consent

Exclusion Criteria:

1. Severe stenosis or occlusion of vertebrobasilar artery and other intracranial arteries (70% - 99%)
2. Left ventricular ejection fraction \< 50% or heart failure
3. Other types of dementia have been diagnosed
4. Severe depression, mental illness, epilepsy
5. Not cooperating with cognitive task evaluation

Where it's running

• Shanghai 6th People's Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Yueqi Zhu, PhD — Shanghai Jiao Tong University Affiliated Sixth People's Hospital
• Study coordinator: Jiangshan Deng, PhD
• Email: johnson120@126.com
• Phone: 862164369181

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ultra-Intensive Lipid-Lowering Therapy in Carotid Artery Stenosis: PCSK9 Inhibitor Plus Statin vs Statin Alone

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• Evaluating a new system for protecting the brain during carotid artery procedures

  This study is testing a new device to see if it can help protect the brain during carotid artery procedures for people with narrowed arteries.

  Recruiting Shenzhen Wecan Medical Technology Co.,Ltd · Beijing · NCT06959628

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.