Impact of body composition on vascular health in healthy-weight females

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how body composition, specifically the ratio of body fat to muscle mass, affects vascular health in females with a healthy body weight. Participants will undergo two different trials: one involving a high-fat meal and the other involving a stress task. During each trial, vascular measurements and blood samples will be collected to assess cardiovascular risk factors. The study aims to provide insights into the relationship between body composition and vascular health, which is not fully captured by BMI alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* You are 18-50 years old
* Your biological sex is female
* BMI is in "normal" category (18.5-24.9 kg/m2) - this BMI requirement is due to our research aims
* You are not pregnant or expecting to become pregnant
* You are not postmenopausal
* You have not been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
* You have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
* You do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs.
* You do not use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs
* You do not have a pacemaker.
* You do not have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies).
* You are able to stay in the supine position in the dark for at least 10 minutes

Exclusion Criteria:

* You are not 18-50 years old
* Your biological sex is not female
* Your BMI is not in the "normal" category (18.5-24.9 kg/m2) - this BMI requirement is due to our research aims
* You are pregnant or expecting to become pregnant (females only)
* You are postmenopausal
* You have been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
* You have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
* You regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs.
* You use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs
* You have a pacemaker.
* You do have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies).
* You are unable to stay in the supine position in the dark for at least 10 minutes

Where it's running

• Ball State University- Nutrition Assessment Lab
  Muncie, Indiana, United States Recruiting

Study contacts

• Study coordinator: Bryant H Keirns, PhD
• Email: bryant.keirns@bsu.edu
• Phone: 7652858356

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.