Impact of Blood Transfusion on Antibiotic Levels in Trauma Patients
Official title: Antibiotic Concentrations After MassivE Transfusion (ACME) Study
Run by Brooke Army Medical Center · NCT06699901 · Data updated 2026-11-12
This study looks at how blood transfusions affect the levels of antibiotics in trauma patients to see if we can improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 417 (estimated) |
| Sponsor | Brooke Army Medical Center Federal |
| Locations | 2 sites (Aurora, Colorado and 1 other locations) |
| Status | Recruiting |
| Started | September 30, 2024 |
| Main results expected | July 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | February 11, 2025 |
| Trial ID | NCT06699901 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include hospitalized trauma patients receiving specific antibiotics and undergoing blood transfusions.
✕Probably not a fit
Patients under 18 years of age, pregnant individuals, or those who have received the same antibiotic recently will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how the volume of blood transfusions affects the plasma concentration of antibiotics in trauma patients. Participants who meet specific trauma criteria and receive certain antibiotics during their hospital stay will be enrolled, with a focus on those undergoing massive transfusions. Blood samples will be collected at multiple time points post-antibiotic infusion to analyze concentration variations. The study aims to enhance understanding of antibiotic dosing in severely wounded patients receiving blood products, utilizing statistical methods for data analysis.
Why it matters
Potential benefit: If successful, this study could lead to improved antibiotic dosing strategies for trauma patients, potentially reducing infection rates.
How similar studies have gone: While the specific relationship between blood transfusion volume and antibiotic concentration is not extensively studied, similar approaches in trauma care have shown promise in improving patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Receives ampicillin/sulbactam, cefazolin, cefepime, ceftriaxone, clindamycin, ertapenem, levofloxacin, metronidazole or pipercillin/tazobactam at any dose * Hospitalized or anticipated hospital admission Exclusion Criteria: * Received the same antibiotic within the past 5 half-lives of the drug (e.g. received the same antibiotic during a recent interval) * \<18 years of age * Known pregnancy * Known Prisoner
Where it's running
-
University of Colorado Hospital
Aurora, Colorado, United States Recruiting -
Brooke Army Medical Center
Fort Sam Houston, Texas, United States Not yet recruiting
Study contacts
- Principal investigator: Julie A Rizzo, MD — Brooke Army Medical Center
- Study coordinator: Steven G Schauer, DO
- Email: steven.g.schauer.mil@army.mil
- Phone: 2109160808
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.