Impact of Bariatric Surgery on Pregnancy and Glucose Levels
Official title: Glucose Homeostasis, Metabolomics and Pregnancy Outcomes After Bariatric Surgery
Run by Universitaire Ziekenhuizen KU Leuven · NCT05084339 · Data updated 2026-11-12
This study is testing how pregnancy and blood sugar levels are affected in women who have had weight loss surgery compared to those who haven't, to see if it helps with pregnancy outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 190 (estimated) |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 8 sites (Aalst and 7 other locations) |
| Status | Recruiting |
| Started | January 25, 2023 |
| Main results expected | September 2026 |
| Study ends | December 2026 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT05084339 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women aged 18-45 with a singleton pregnancy and a history of gastric bypass or sleeve gastrectomy.
✕Probably not a fit
Patients with multiple pregnancies, pregestational diabetes, or other types of bariatric surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The GLORIA study is a multicenter observational cohort study in Belgium that aims to investigate how altered glucose metabolism and metabolomics during pregnancy after bariatric surgery affect pregnancy outcomes. It will recruit 95 pregnant women who have undergone bariatric surgery and a control group of 95 pregnant women without such surgery. Continuous glucose monitoring (CGM) will be utilized to assess glycaemia levels and variability throughout pregnancy, alongside anthropometric measurements and dietary assessments. The study will also explore the potential of CGM in diagnosing gestational diabetes.
Why it matters
Potential benefit: If successful, this study could improve understanding of pregnancy risks for women post-bariatric surgery and enhance monitoring for gestational diabetes.
How similar studies have gone: While similar studies have explored glucose metabolism in pregnancy, this specific approach combining CGM and metabolomics in post-bariatric surgery patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-45 years and with a singleton pregnancy with ultrasound-confirmed gestational age up to 11 weeks and 6 days * for the group with bariatric surgery: history of gastric bypass (RYBG) or sleeve gastrectomy (SG) * Participants need to speak and understand Flemish, French or English and have e-mail access. Exclusion Criteria: * multiple pregnancy * pregnancy ≥12 weeks * other types of bariatric surgery than RYBG or SG * known pregestational diabetes * a physical or psychological disease likely to interfere with the conduct of the study * medications known to interfere with glucose metabolism.
Where it's running
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OLV-Aalst-Asse
Aalst, Belgium Recruiting -
Uza
Antwerp, Belgium Recruiting -
ZNA Antwerpen
Antwerp, Belgium Recruiting -
Imelda Bonheiden
Bonheiden, Belgium Recruiting -
AZ St-Jan Brugge
Bruges, Belgium Recruiting -
UZ Gent
Ghent, Belgium Recruiting
Show 2 more locations
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AZ Groeninge Kortrijk
Kortrijk, Belgium Recruiting -
UZ Leuven
Leuven, Belgium Recruiting
Study contacts
- Principal investigator: Katrien Benhalima, MD PhD — UZ Leuven
- Study coordinator: Katrien Benhalima, MD PhD
- Email: katrien.benhalima@uzleuven.be
- Phone: +3216340614
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Impact of obesity, diabetes, and bariatric surgery on pregnancy outcomes
This study looks at how being overweight, having diabetes, or having had weight-loss surgery affects pregnancy outcomes for women compared to those with a normal weight.
-
Comparing glucose monitoring methods in pregnant women with gestational diabetes after gastric bypass surgery
This study is testing whether continuous glucose monitoring works better than traditional blood sugar checks for pregnant women with gestational diabetes who have had gastric bypass surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.