Immune pathways and genetic factors in SAPHO syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will enroll adults with a confirmed diagnosis of SAPHO syndrome at two Paris hospitals to collect biological samples for laboratory study. Researchers will perform deep immune phenotyping of circulating leukocytes—focusing on neutrophil subsets, neutrophil extracellular traps (NETs), and Th17 cells—alongside protein profiling. The study will also conduct genetic analyses to search for variants associated with SAPHO in a European/Caucasian population, addressing gaps from prior smaller or non-European studies. Results will help identify over- or under-represented cell populations and candidate genes that may contribute to disease mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient aged ≥ 18 years
* Patient diagnosed with SAPHO syndrome
* Weight \> 35 kg
* Patient affiliated with a health insurance plan
* French-speaking patient
* Patient who has given free, informed, and written consent

Exclusion Criteria:

* Patient under guardianship or curatorship
* Patient deprived of liberty
* Patient under legal protection
* Pregnant or breastfeeding patient

Where it's running

• Hôpital Cochin
  Paris, France Recruiting
• Hôpital Paris Saint Joseph
  Paris, France Recruiting

Study contacts

• Study coordinator: Olivier Fogel, MD
• Email: olivier.fogel@aphp.fr
• Phone: +331 58 41 13 70

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.