Immediate implant with bone graft taken from the maxillary tuberosity to improve upper front-tooth esthetics.
Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series
This trial tries placing an implant immediately after extraction and using bone taken from the maxillary tuberosity to improve bone thickness, gum support, and esthetic outcomes for adults needing a single upper front-tooth replacement.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City Academic / other |
| Locations | 1 site (Ho Chi Minh City, Ho Chi Minh) |
| Trial ID | NCT07460076 on ClinicalTrials.gov |
What this trial studies
This prospective interventional case series combines immediate implant placement in the maxillary esthetic zone with a two-layer autogenous graft harvested from the maxillary tuberosity (cortical bone plus connective tissue). Patients requiring extraction and a single upper-front implant receive the graft at the time of implant placement and are followed with clinical exams and cone-beam CT imaging. Primary outcomes are buccal bone thickness on CBCT, facial soft tissue thickness measured clinically, and the pink esthetic score after definitive restoration. Follow-up assessments will track radiographic and esthetic changes to determine whether the tuberosity graft improves peri-implant tissue stability.
Who should consider this trial
Good fit: Adults who need a single implant in the maxillary esthetic zone, are candidates for immediate implant placement, and have a buccal bone defect suitable for augmentation with a maxillary tuberosity autograft.
Not a fit: Patients with uncontrolled systemic disease, prior head and neck radiotherapy, active oral infection, heavy smoking, insufficient bone for the planned protocol, or severe parafunctional habits are unlikely to benefit.
Why it matters
Potential benefit: If successful, this approach could increase buccal bone and soft-tissue support around immediate upper-front implants, improving esthetic scores and long-term stability.
How similar studies have performed: Small case series and clinical reports have reported promising bone and esthetic results with maxillary tuberosity autografts, but high-quality randomized trials are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older * Patients requiring single implant placement in the maxillary esthetic zone * Indication for immediate implant placement following tooth extraction * Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft * Adequate oral hygiene and ability to maintain postoperative care * Willingness to participate in the study and provide informed consent Exclusion Criteria: * Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases * History of radiotherapy in the head and neck region * Active periodontal disease or untreated oral infection * Heavy smoking (more than 10 cigarettes per day) * Pregnancy or lactation * Severe parafunctional habits * Insufficient bone volume preventing implant placement with the planned protocol * Patients unable to attend follow-up visits
Where this trial is running
Ho Chi Minh City, Ho Chi Minh
- University of Medicine and Pharmacy at Ho Chi Minh City — Ho Chi Minh City, Ho Chi Minh, Vietnam (Recruiting)
Study contacts
- Study coordinator: Duy Anh Tran, DDS
- Email: tranduyanhump17@gmail.com
- Phone: +84 868324216
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.