Imaging the heart's metabolism using a special carbon-13 compound

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a novel imaging technique using hyperpolarized carbon-13 pyruvate injection to assess heart metabolism in individuals with hypertension and hypertrophy. Participants will undergo MRI scans after receiving a glucose drink to optimize imaging results. The goal is to gain insights into heart failure treatments by visualizing biochemical reactions in the heart, potentially leading to earlier interventions and improved patient outcomes. The study will compare different labeling patterns of the pyruvate to gather comprehensive metabolic data.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Written consent
* Age: 19 to 50 in Arm 1, 30 to 75 in Arm 2
* Group 2A and 2E participants have left-ventricular hypertrophy
* Group 2B and 2F participants have diagnosed hypertrophic cardiomyopathy
* Group 2C and 2G participants are stable outpatients with NYHA class 1-3 heart failure with evidence of elevated LV mass (LVH), irrespective of LVEF.
* Group 2D and 2H participants are stable patients with type 2 DM who have a HcA1c between 6.5-9% on oral hypoglycemic agents

Exclusion Criteria

* Contraindications to MRI or MRI contrast agents
* Hemoglobin ≤ 9.0 gm/dL (only Group 2 participants)
* Glomerular filtration rate (based on MDRD Equation) \< 30 ml/min/1.73m2 (only Group 2 participants)
* Any condition leading to a life expectancy \<1 year
* Medically diagnosed claustrophobia
* Have received, or are scheduled to receive, another investigational medicinal product from 1 month prior to 1 month after inclusion in this study
* BMI of less than 18.5 or greater than 32
* Group 1: medically diagnosed heart disease

Where it's running

• Sunnybrook Health Sciences Centre
  Toronto, Ontario, Canada Recruiting
• St. Michael's Hospital
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Charles Cunningham, PhD — Sunnybrook Research Institute
• Study coordinator: Norberto Garcia
• Email: norberto.garcia@sunnybrook.ca
• Phone: 4164806100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.