Imaging techniques to improve diagnosis of epilepsy in children
Official title: Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
Run by The University of Texas Health Science Center, Houston · NCT02846272 · Data updated 2026-11-12
This study is testing new MRI techniques to see if they can help doctors better diagnose epilepsy in children who have severe, hard-to-treat cases.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 0 Days to 18 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | November 2015 |
| Main results expected | January 1, 2030 |
| Study ends | January 1, 2031 |
| Registry record updated | December 11, 2024 |
| Trial ID | NCT02846272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children diagnosed with intractable epilepsy who are being considered for surgical intervention.
✕Probably not a fit
Patients who do not have a diagnosis of intractable epilepsy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of diffusion tensor and functional connectivity magnetic resonance imaging (MRI) in the preoperative assessment of children with intractable epilepsy. Participants will undergo standard MRI procedures along with a 15-minute session of advanced imaging techniques without the need for additional sedation. The collected imaging data will be anonymized and analyzed to provide insights into brain connectivity and the structure of white matter tracts near epileptogenic areas. The goal is to enhance the understanding and diagnosis of intractable epilepsy in pediatric patients.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment planning for children suffering from intractable epilepsy.
How similar studies have gone: Other studies utilizing advanced MRI techniques have shown promise in improving the understanding of epilepsy, suggesting that this approach may yield beneficial results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children diagnosis with Intractable Epilepsy Exclusion Criteria: * No Intractable Epilepsy
Where it's running
-
UTHealth & Children's Memorial Hermann Hospital
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Manish N Shah, M.D. — UTHealth Medical School
- Study coordinator: Manish N Shah, M.D.
- Email: Manish.N.Shah@uth.tmc.edu
- Phone: 713 500-7410
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.