Imaging techniques to improve diagnosis of epilepsy in children
Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
This study is testing new MRI techniques to see if they can help doctors better diagnose epilepsy in children who have severe, hard-to-treat cases.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 0 Days to 18 Years |
| Sex | All |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT02846272 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of diffusion tensor and functional connectivity magnetic resonance imaging (MRI) in the preoperative assessment of children with intractable epilepsy. Participants will undergo standard MRI procedures along with a 15-minute session of advanced imaging techniques without the need for additional sedation. The collected imaging data will be anonymized and analyzed to provide insights into brain connectivity and the structure of white matter tracts near epileptogenic areas. The goal is to enhance the understanding and diagnosis of intractable epilepsy in pediatric patients.
Who should consider this trial
Good fit: Ideal candidates for this study are children diagnosed with intractable epilepsy who are being considered for surgical intervention.
Not a fit: Patients who do not have a diagnosis of intractable epilepsy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment planning for children suffering from intractable epilepsy.
How similar studies have performed: Other studies utilizing advanced MRI techniques have shown promise in improving the understanding of epilepsy, suggesting that this approach may yield beneficial results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children diagnosis with Intractable Epilepsy Exclusion Criteria: * No Intractable Epilepsy
Where this trial is running
Houston, Texas
- UTHealth & Children's Memorial Hermann Hospital — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Manish N Shah, M.D. — UTHealth Medical School
- Study coordinator: Manish N Shah, M.D.
- Email: Manish.N.Shah@uth.tmc.edu
- Phone: 713 500-7410
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.