Imaging of heart and lung changes after childhood cancer treatment in ALL or lymphoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare survivors of childhood ALL or lymphoma who are now long-term patients with healthy controls. They will use low-field MRI, multispectral optoacoustic tomography, spirometry, DLCO, echocardiography with strain analysis, and ECG, along with questionnaires about physical and mental health. The goal is to validate and expand findings on ventilation and perfusion defects and reduced aerobic capacity, and to characterize long-term cardiopulmonary effects after childhood cancer treatment. This multicenter follow-up study will focus on individuals at least 5 years post-treatment and will assess structural and functional changes in the lungs and heart. Safety and feasibility of the imaging approaches in this population will also be evaluated.

Why it matters

Who can join: the full rules

Control Group:

Inclusion Criteria:

* no cancer diagnosis
* no lung diseases
* no vascular diseases
* No subjective reduction in physical performance
* age \>/= 18 years

Exclusion Criteria:

* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)

Survivors of ALL:

Inclusion Criteria:

* Completed therapy for ALL
* age \>/= 3 years

Exclusion Criteria:

* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)

Survivors of Lymphoma:

Inclusion Criteria:

* Completed therapy for lymphoma
* age \>/= 3 years

Exclusion Criteria:

* Pregnancy, Lactation
* Known pleural or pericardial effusion
* Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
* Marked thoracic deformities/malformations
* Previous lung surgery
* Injuries that do not allow physical stress diagnostics
* Rejection of MRI imaging
* General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)

Where it's running

• Department of Pediatrics and Adolescent Medicine
  Erlangen, Germany Recruiting

Study contacts

• Study coordinator: Axel Karow, PD. Dr. med.
• Email: axel.karow@uk-erlangen.de
• Phone: 09131 8533118

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.