Imaging of atherosclerotic plaques in arteries using advanced MRI techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the imaging of atherosclerotic plaques in both intracranial and extracranial arteries using high-resolution vessel wall imaging (HR-VWI) technology. By utilizing advanced MRI techniques, the study seeks to enhance the visualization of arterial wall morphology and plaque characteristics, which are crucial for assessing the risk of ischemic cerebrovascular events. Participants will receive two intravenous injections of a gadoterate meglumine contrast agent to facilitate this imaging process. The study focuses on patients with moderate to severe arterial stenosis, aiming to provide clearer insights into plaque composition and vulnerability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years;
* Moderate to severe intracranial or extracranial arterial stenosis (stenosis degree: 50% to 99%, confirmed by CTA, MRA, or DSA);
* Written informed consent signed by the patient or their legal representative.

Exclusion Criteria:

* Non-atherosclerotic intracranial arterial stenosis, such as dissection or moyamoya disease;
* Contraindications to MRI, such as claustrophobia or presence of a cardiac pacemaker;
* Allergy to gadolinium-based contrast agents;
* Poor MRI image quality preventing analysis;
* Abnormal liver or kidney function;
* History of any prior endovascular treatment;
* Presence of implants posing potential safety risks in 5.0T MRI, such as non-removable metallic dental prostheses, stents, or other metallic implants.

Where it's running

• Shanghai Sixth People's Hospital, Shanghai,200023
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yueqi Zhu
• Email: zhuyeuqi@hotmail.com
• Phone: +86-21-66301136

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.