Imaging neuroblastoma using 68Ga-DOTATATE

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to evaluate the feasibility and safety of using 68Ga-DOTATATE PET/CT imaging in patients with neuroblastoma or those suspected of having the disease. It will compare the imaging results of 68Ga-DOTATATE with the traditional 123I-MIBG imaging method in the same participants. The study will involve children and adults who meet specific eligibility criteria, and data will be collected over a two-year period following the imaging procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Newly suspected or biopsy-proven neuroblastoma or recurrence of neuroblastoma
* Planned 123I-MIBG imaging
* Able and willing to provide signed informed consent in French or English (for the adult candidates or the parent/legal tutor of the pediatric candidates)
* Aged between 1 day and 21 years old (inclusively).

Exclusion Criteria:

* History of another cancer in the past 5 years other than non-melanomatous skin cancer.
* Currently under a randomized control trial with unknown allocation;
* Currently under treatment;
* Medical/surgical intervention on the tumour between 123I-MIBG and 68Ga-DOTATATE PET/CT scan.
* Medically unstable or unable to undergo scan.
* Pregnancy (breastfeeding is not an exclusion criterion but needs to be stopped for at least 12 hours after 68Ga-DOTATATE injection).
* Prior allergic reaction to somatostatin analogues

Where it's running

• CHU Ste-Justine
  Montreal, Quebec, Canada Recruiting
• CIUSSS de l'Estrie-CHUS Hospital
  Sherbrooke, Quebec, Canada Recruiting
• McGill University Health Center - Children's hospital
  Montreal, Quebec, Canada Withdrawn

Study contacts

• Principal investigator: Etienne Rousseau, MD, FRCPC — Ciussse-Chus
• Study coordinator: Amelie Tetu, MSc
• Email: amelie.tetu.ciussse-chus@ssss.gouv.qc.ca
• Phone: 819-346-1110

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.