Imaging lung health in young adults using Hyperpolarized 129Xe MRI
Hyperpolarized 129Xe MRI to Identify Structural Determinants of Low Lung Function and Respiratory Symptoms in Young Adults From the Lung Health Cohort
This study is testing a special type of MRI to see how healthy the lungs are in young adults and to find any early signs of lung problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 260 (estimated) |
| Ages | 25 Years to 35 Years |
| Sex | All |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 6 sites (Chicago, Illinois and 5 other locations) |
| Trial ID | NCT05766384 on ClinicalTrials.gov |
What this trial studies
This observational study involves a subset of young adults from the American Lung Association Lung Health Cohort who will undergo imaging with Hyperpolarized 129Xe MRI. The goal is to assess lung structure and function, providing insights into lung health and identifying early abnormalities that could lead to chronic lung diseases. Participants must have previously completed CT imaging as part of the Lung Health Cohort within the last two years. The study aims to enhance understanding of lung health through advanced imaging techniques.
Who should consider this trial
Good fit: Ideal candidates are young adults enrolled in the American Lung Association Lung Health Cohort who have had recent CT imaging.
Not a fit: Patients with implanted electronic devices, those who are pregnant or breastfeeding, or individuals with low oxygen saturation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and understanding of lung abnormalities, potentially preventing chronic lung diseases.
How similar studies have performed: Other studies using advanced imaging techniques have shown promise in understanding lung health, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Is enrolled in the American Lung Association Lung Health Cohort Study. * Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date. Exclusion Criteria: * Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution). * Is pregnant or breastfeeding * Oxygen saturation (SpO2) \<88% on room air or with supplemental oxygen.
Where this trial is running
Chicago, Illinois and 5 other locations
- University of Illinois-Chicago — Chicago, Illinois, United States (Not_yet_recruiting)
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
- University of Kansas Medical Center — Kansas City, Kansas, United States (Recruiting)
- Duke University — Durham, North Carolina, United States (Recruiting)
- Baylor College of Medicine — Houston, Texas, United States (Not_yet_recruiting)
- MD Anderson Cancer Center — Houston, Texas, United States (Not_yet_recruiting)
Study contacts
- Study coordinator: Cristal Monge
- Email: chernandez@kumc.edu
- Phone: 913-945-9399
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.