Imaging lung health in young adults using Hyperpolarized 129Xe MRI
Official title: Hyperpolarized 129Xe MRI to Identify Structural Determinants of Low Lung Function and Respiratory Symptoms in Young Adults From the Lung Health Cohort
Run by University of Kansas Medical Center · NCT05766384 · Data updated 2026-11-12
This study is testing a special type of MRI to see how healthy the lungs are in young adults and to find any early signs of lung problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 25 Years to 35 Years |
| Sex | All |
| Enrollment | 260 (estimated) |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 6 sites (Chicago, Illinois and 5 other locations) |
| Status | Recruiting |
| Started | November 30, 2023 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT05766384 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young adults enrolled in the American Lung Association Lung Health Cohort who have had recent CT imaging.
✕Probably not a fit
Patients with implanted electronic devices, those who are pregnant or breastfeeding, or individuals with low oxygen saturation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study involves a subset of young adults from the American Lung Association Lung Health Cohort who will undergo imaging with Hyperpolarized 129Xe MRI. The goal is to assess lung structure and function, providing insights into lung health and identifying early abnormalities that could lead to chronic lung diseases. Participants must have previously completed CT imaging as part of the Lung Health Cohort within the last two years. The study aims to enhance understanding of lung health through advanced imaging techniques.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and understanding of lung abnormalities, potentially preventing chronic lung diseases.
How similar studies have gone: Other studies using advanced imaging techniques have shown promise in understanding lung health, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Is enrolled in the American Lung Association Lung Health Cohort Study. * Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date. Exclusion Criteria: * Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution). * Is pregnant or breastfeeding * Oxygen saturation (SpO2) \<88% on room air or with supplemental oxygen.
Where it's running
-
University of Iowa
Iowa City, Iowa, United States Recruiting -
University of Kansas Medical Center
Kansas City, Kansas, United States Recruiting -
Duke University
Durham, North Carolina, United States Recruiting -
University of Illinois-Chicago
Chicago, Illinois, United States Not yet recruiting -
Baylor College of Medicine
Houston, Texas, United States Not yet recruiting -
MD Anderson Cancer Center
Houston, Texas, United States Not yet recruiting
Study contacts
- Study coordinator: Cristal Monge
- Email: chernandez@kumc.edu
- Phone: 913-945-9399
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.