Imaging cholesterol trafficking in healthy individuals using a new PET tracer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This exploratory phase 0 study aims to evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) for imaging the adrenal gland in healthy subjects. The study focuses on assessing the imaging characteristics of [18F]FNP-59, which is expected to provide improved radiation dosimetry compared to existing methods. Following the initial results, further studies will be conducted involving hormone manipulation in subsequent groups. The goal is to enhance the understanding of cholesterol trafficking in the body.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants without any known adrenal pathology as normal controls for radiation dosimetry purposes

Exclusion Criteria:

* Pregnancy
* Unable to do imaging
* Body weight greater than 400 lbs (181 Kg)
* Prisoners are not eligible
* Subjects unable to provide own consent are not eligible
* Current use of steroids, Oral contraceptives (OCP), spironolactone, estrogen, androgen, progesterone, Angiotensin-converting enzyme (ACE inhibitors)/ Angiotensin II receptor blockers (ARBs), or supplements that are hormone analogues.
* Known adrenal pathology

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Ben Viglianti, M.D, Ph.D. — University of Michigan
• Study coordinator: Jim Pool
• Email: jampool@umich.edu
• Phone: 734-615-7391

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.